PDF(Pubmed)
Abstract：
5-Fluorouracil (5-FU) and its prodrug, capecitabine, are commonly used chemotherapeutic agents for solid tumor management. While these agents can present with adverse side effects such as nausea, vomiting, diarrhea, and myelosuppression, they can also, less commonly, cause cardiovascular toxicity. This toxicity may manifest as cardiac arrhythmias, myocarditis, heart failure, myocardial infarction, and even death. The management of 5-FU-related cardiotoxicity includes early recognition of symptom manifestation so that medication can be discontinued promptly and symptoms can be addressed appropriately. Here, we describe the case of a 72-year-old male who developed coronary vasospasm and ST-segment elevation myocardial infarction shortly after the initiation of chemotherapy with 5-FU.
摘要：
5-氟尿嘧啶（5-FU）及其前药，卡培他滨,是用于实体瘤管理的常用化学治疗剂。虽然这些药物可能会出现不良副作用，如恶心，呕吐,腹泻,和骨髓抑制，他们也可以,不太常见，引起心血管毒性。这种毒性可能表现为心律失常，心肌炎,心力衰竭,心肌梗塞,甚至死亡。5-FU相关心脏毒性的管理包括早期识别症状表现，以便可以及时停药并适当解决症状。这里,我们描述了一例72岁男性患者,他在开始5-FU化疗后不久出现了冠状动脉血管痉挛和ST段抬高型心肌梗死.
