目的:为了获得T2加权成像(T2WI)的诊断准确性,和动态对比增强MRI(DCE-MRI)在子宫内膜癌(EC)患者宫颈侵犯的术前评估中的应用。
方法:包括PubMed、Embase,科克伦图书馆,WebofScience,并在临床试验中搜索了2000年1月至2020年8月发表的相关文章。通过统计分析获得汇总的估计数据。
结果:总计,包括24篇文章。为了评估EC的宫颈浸润,汇集的敏感性,特异性,正似然比(PLR),负似然比(NLR),诊断优势比(DOR),T2WI的曲线下面积(AUC)为0.70(0.61-0.77),0.92(0.89-0.94),8.7(6.5-11.6),0.33(0.25-0.43),26(17-41)和0.92(0.89-0.94),分别。对于DCE-MRI,汇集的敏感性,特异性,PLR,NLR,DOR,AUC为0.75(0.60-0.85),0.95(0.89-0.98),14.7(6.6-32.9),0.27(0.16-0.44),55(18-165)和0.92(0.89-0.94),对于T2WI联合DCE-MRI,它们是0.58(0.41-0.73),0.98(0.95-0.99),28.1(12.8-62.1),0.43(0.30-0.63),65(29-146),和0.94(0.91-0.96),分别。
结论:DCE-MRI在预测EC患者宫颈侵犯方面显示出比T2WI更高的诊断性能。T2WI联合DCE-MRI提高了合并特异性,PLR,DOR,和AUC与单独的T2WI或单独的DCE-MRI相比。
OBJECTIVE: To obtain the diagnostic accuracy of T2-weighted imaging (T2WI), and dynamic contrast-enhanced MRI (DCE-MRI) in the preoperative assessment of cervical invasion in patients with endometrial cancer (EC).
METHODS: Databases including PubMed, Embase, Cochrane Library, Web of Science, and Clinical Trials were searched for relevant articles published from January 2000 to August 2020. Pooled estimation data were obtained by statistical analysis.
RESULTS: In total, 24 articles were included. For assessing cervical invasion of EC, the pooled sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR), and area under the curve (AUC) for T2WI were 0.70 (0.61-0.77), 0.92 (0.89-0.94), 8.7 (6.5-11.6), 0.33 (0.25-0.43), 26 (17-41), and 0.92 (0.89-0.94), respectively. For DCE-MRI, the pooled sensitivity, specificity, PLR, NLR, DOR, and AUC were 0.75 (0.60-0.85), 0.95 (0.89-0.98), 14.7 (6.6-32.9), 0.27 (0.16-0.44), 55 (18-165), and 0.92 (0.89-0.94), respectively; for T2WI combined with DCE-MRI, they were 0.58 (0.41-0.73), 0.98 (0.95-0.99), 28.1 (12.8-62.1), 0.43 (0.30-0.63), 65 (29-146), and 0.94 (0.91-0.96), respectively.
CONCLUSIONS: DCE-MRI demonstrated higher diagnostic performance than T2WI in the prediction of cervical invasion in patients with EC. T2WI combined with DCE-MRI improved the pooled specificity, PLR, DOR, and AUC compared to T2WI alone or DCE-MRI alone.