Abstract：
OBJECTIVE: The aim of this study was to evaluate clinical significance of depth of myometrial invasion and cervical invasion by magnetic resonance imaging (MRI) in patients with endometrial carcinoma.
METHODS: Between September 2011 and October 2014 on 98 patients who were diagnosed with and treated for endometrial carcinoma at Subei People\'s Hospital in China included in this study. Main outcome measure was the correlation between the depth of myometrial invasion and cervical invasion by preoperative MRI, transvaginal sonography, hysteroscopy with directed biopsy study and the subsequent histopathological findings following examination of the hysterectomy specimen.
RESULTS: The mean age was 54.6 years old and the most common histological subtype was the endometrioid type of endometrial adenocarcinoma (87.8%). In the evaluation of deep myometrial invasion (>50%), sensitivity, specificity, positive and negative predictive value and positive and negative likelihood ratios of MRI were 70.00%, 94.87%, 77.78%, 92.50%, 13.65, 0.316, respectively. For cervical invasion, these values were 72.73%, 98.85%, 88.89%, 96.63%, 63.27, 0.30, respectively.
CONCLUSIONS: MRI is the superior diagnostic method to detect the myometrial invasion and cervical invasion.
METHODS: Between September 2011 and October 2014 on 98 patients who were diagnosed with and treated for endometrial carcinoma at Subei People\'s Hospital in China included in this study. Main outcome measure was the correlation between the depth of myometrial invasion and cervical invasion by preoperative MRI, transvaginal sonography, hysteroscopy with directed biopsy study and the subsequent histopathological findings following examination of the hysterectomy specimen.
RESULTS: The mean age was 54.6 years old and the most common histological subtype was the endometrioid type of endometrial adenocarcinoma (87.8%). In the evaluation of deep myometrial invasion (>50%), sensitivity, specificity, positive and negative predictive value and positive and negative likelihood ratios of MRI were 70.00%, 94.87%, 77.78%, 92.50%, 13.65, 0.316, respectively. For cervical invasion, these values were 72.73%, 98.85%, 88.89%, 96.63%, 63.27, 0.30, respectively.
CONCLUSIONS: MRI is the superior diagnostic method to detect the myometrial invasion and cervical invasion.
摘要：
目的：本研究的目的是通过磁共振成像（MRI）评估子宫内膜癌患者子宫肌层浸润深度和宫颈浸润深度的临床意义。
方法：2011年9月至2014年10月在中国苏北人民医院诊断并治疗的98例子宫内膜癌患者纳入本研究。主要结局指标为术前MRI检查子宫肌层浸润深度与宫颈浸润的相关性,经阴道超声检查,宫腔镜检查与定向活检研究和随后的组织病理学发现后，检查子宫切除术标本。
结果：平均年龄为54.6岁，最常见的组织学亚型是子宫内膜样腺癌（87.8％）。在评估深肌层浸润(>50%)时，灵敏度,特异性，MRI的阳性和阴性预测值以及阳性和阴性似然比为70.00%,94.87%,77.78%,92.50%,分别为13.65、0.316。对于宫颈侵犯，这些值是72.73%，98.85%,88.89%,96.63%,分别为63.27、0.30。
结论：MRI是检测子宫肌层侵犯和宫颈侵犯的较好诊断方法。
方法：2011年9月至2014年10月在中国苏北人民医院诊断并治疗的98例子宫内膜癌患者纳入本研究。主要结局指标为术前MRI检查子宫肌层浸润深度与宫颈浸润的相关性,经阴道超声检查,宫腔镜检查与定向活检研究和随后的组织病理学发现后，检查子宫切除术标本。
结果：平均年龄为54.6岁，最常见的组织学亚型是子宫内膜样腺癌（87.8％）。在评估深肌层浸润(>50%)时，灵敏度,特异性，MRI的阳性和阴性预测值以及阳性和阴性似然比为70.00%,94.87%,77.78%,92.50%,分别为13.65、0.316。对于宫颈侵犯，这些值是72.73%，98.85%,88.89%,96.63%,分别为63.27、0.30。
结论：MRI是检测子宫肌层侵犯和宫颈侵犯的较好诊断方法。
