■关于循环类胡萝卜素和死亡风险的流行病学证据仍然相互矛盾,大多数研究集中在单个类胡萝卜素的影响上。本研究旨在阐明共同接触多种血清类胡萝卜素对死亡风险的影响。
■我们从国家健康与营养调查(NHANES)III(1988-1994)和NHANES2003-2006招募了22,472名年龄≥20岁的参与者。五种主要类胡萝卜素的基线血清水平(α-胡萝卜素,β-胡萝卜素,番茄红素,β-隐黄质,和叶黄素/玉米黄质)进行测量,和个人随访至2019年12月31日。使用K均值方法鉴定类胡萝卜素共暴露模式。Cox比例风险模型用于研究类胡萝卜素暴露与死亡风险之间的关系。
■在16.7年的中位随访期间,7901人死亡。K-means将参与者聚集到低层次,低番茄红素,高番茄红素,和高水平暴露组。在完全调整的模型中,低番茄红素,高番茄红素,与低水平暴露组相比,高水平暴露组的全因死亡风险显着降低,风险比(HR)和95%置信区间(CI)为0.79(0.72,0.87),0.75(0.67,0.84),和0.67(0.61,0.74),分别。对于心血管疾病死亡率,高番茄红素暴露组的风险降低了27%(HR:0.73,95%CI:0.61-0.86),高水平暴露组的风险降低了21%(HR:0.79,95%CI:0.67-0.93).对于癌症死亡率,高番茄红素和高水平暴露组的风险降低了30%和35%,HR(95%CI)为0.70(0.57,0.86)和0.65(0.54,0.79),分别。
■这项研究表明,共同接触多种血清类胡萝卜素与降低死亡风险有关,强调增加类胡萝卜素摄入的潜在健康益处。需要进一步研究以阐明不同类胡萝卜素之间相互作用的潜在机制。
UNASSIGNED: Epidemiological evidence regarding circulating carotenoids and mortality risk remains conflicting, and most studies focus on the impact of individual carotenoids. This study aimed to elucidate the effects of co-exposure to multiple serum carotenoids on mortality risk.
UNASSIGNED: We enrolled 22,472 participants aged ≥20 from the National Health and Nutrition Examination Survey (NHANES) III (1988-1994) and NHANES 2003-2006. Baseline serum levels of five major carotenoids (α-carotene, β-carotene, lycopene, β-cryptoxanthin, and lutein/zeaxanthin) were measured, and individuals were followed up until December 31, 2019.
Carotenoid co-exposure patterns were identified using the K-means method. Cox proportional hazard models were used to investigate the associations between
carotenoid exposure and mortality risk.
UNASSIGNED: During a median follow-up of 16.7 years, 7,901 deaths occurred. K-means clustered participants into low-level, low-lycopene, high-lycopene, and high-level exposure groups. In the fully adjusted model, low-lycopene, high-lycopene, and high-level exposure groups had significantly lower all-cause mortality risks compared to the low-level exposure group, with hazard ratios (HRs) and 95% confidence intervals (CIs) of 0.79 (0.72, 0.87), 0.75 (0.67, 0.84), and 0.67 (0.61, 0.74), respectively. For cardiovascular disease mortality, the high-lycopene exposure group had a 27% reduced risk (HR: 0.73, 95% CI: 0.61-0.86), and the high-level exposure group had a 21% reduced risk (HR: 0.79, 95% CI: 0.67-0.93). For cancer mortality, the high-lycopene and high-level exposure groups had 30% and 35% lower risks, with HRs (95% CIs) of 0.70 (0.57, 0.86) and 0.65 (0.54, 0.79), respectively.
UNASSIGNED: This study revealed that co-exposure to multiple serum carotenoids was associated with reduced mortality risk, highlighting the potential health benefits of increased
carotenoid intake. Further investigation is warranted to elucidate the underlying mechanisms of interactions among different carotenoids.