心血管疾病对人类健康构成严重威胁。心血管疾病的发病涉及多基因和环境因素的综合作用,多种信号通路参与调节心血管疾病的发生和发展。Hippo通路是一条高度保守的信号通路,参与细胞增殖的调控,凋亡,和差异化。最近,它在心血管疾病领域得到了广泛的研究,癌症,和细胞再生。非编码RNA(ncRNAs),它们是调节细胞中基因表达的重要小分子,可以直接靶向基因并具有多种调节功能。最近的研究发现ncRNAs与Hippo通路组分相互作用以调节心肌纤维化,心肌细胞增殖,凋亡,和肥大,在心血管疾病中起重要作用。在这次审查中,我们描述了ncRNAs在调节Hippo途径中的作用模式,为进一步的研究提供新的思路,并鉴定参与ncRNAs和Hippo途径作用机制的分子作为潜在的治疗靶标,目的是寻找治疗和预防心血管疾病的新的作用方式。
Cardiovascular diseases pose a serious threat to human health. The onset of cardiovascular diseases involves the comprehensive effects of multiple genes and environmental factors, and multiple signaling pathways are involved in regulating the occurrence and development of cardiovascular diseases. The Hippo pathway is a highly conserved signaling pathway involved in the regulation of cell proliferation, apoptosis, and differentiation. Recently, it has been widely studied in the fields of cardiovascular disease, cancer, and cell regeneration. Non-coding RNA (ncRNAs), which are important small molecules for the regulation of gene expression in cells, can directly target genes and have diverse regulatory functions. Recent studies have found that ncRNAs interact with Hippo pathway components to regulate myocardial fibrosis, cardiomyocyte proliferation, apoptosis, and hypertrophy and play an important role in cardiovascular disease. In this review, we describe the mode of action of ncRNAs in regulating the Hippo pathway, provide new ideas for further research, and identify molecules involved in the mechanism of action of ncRNAs and the Hippo pathway as potential therapeutic targets, with the aim of finding new modes of action for the treatment and prevention of cardiovascular diseases.