PDF(Pubmed)
Abstract：
Placental insufficiency is one of the major causes of fetal growth restriction (FGR), a significant pregnancy disorder in which the fetus fails to achieve its full growth potential in utero. As well as the acute consequences of being born too small, affected offspring are at increased risk of cardiovascular disease, diabetes and other chronic diseases in later life. The placenta and heart develop concurrently, therefore placental maldevelopment and function in FGR may have profound effect on the growth and differentiation of many organ systems, including the heart. Hence, understanding the key molecular players that are synergistically linked in the development of the placenta and heart is critical. This review highlights the key growth factors, angiogenic molecules and transcription factors that are common causes of defective placental and cardiovascular development.
摘要：
胎盘功能不全是胎儿生长受限（FGR）的主要原因之一，一种严重的妊娠疾病，其中胎儿未能在子宫内实现其全部生长潜力。以及出生太小的严重后果，受影响的后代患心血管疾病的风险增加，糖尿病和其他慢性疾病在以后的生活。胎盘和心脏同时发育，因此，FGR中胎盘发育异常和功能可能对许多器官系统的生长和分化产生深远的影响，包括心脏。因此，了解在胎盘和心脏发育过程中协同联系的关键分子因素至关重要。这篇综述强调了关键的增长因素，血管生成分子和转录因子是胎盘和心血管发育缺陷的常见原因。
