■阿斯巴甜,由GD-Searle于1965年发明,是一种强烈的人造甜味剂,味道是蔗糖的200倍,并在6000多种产品中用作添加剂。阿斯巴甜(APM)于1980年初提交上市前安全性评估。研究,由GD-Searle表演,产生了有争议的结果。
■由于阿斯巴甜的巨大商业传播,1997年,Ramazzini研究所(RI)启动了一个大型的啮齿动物实验项目,以测试阿斯巴甜的致癌作用,遵循具有更敏感特征的实验模型,即大量的老鼠,从产前生活开始治疗,观察直到自发死亡。总的来说,该项目包括研究2270只大鼠和852只小鼠。这些研究表明,阿斯巴甜是实验动物的致癌物质,诱导几种类型的恶性肿瘤的显著剂量相关的发病率增加,其中,血液肿瘤,还有肝癌.
■Ramazzini研究所对阿斯巴甜的这些研究结果为评估人造甜味剂及其可能的健康风险开辟了一条真正的战线。对其他弥漫性人造甜味剂(如安赛蜜)进行足够的长期致癌性生物测定,三氯半乳蔗糖,糖精,包括它们的混合物,对公众健康同样重要。
UNASSIGNED: Aspartame, invented in 1965 by GD-Searle, is an intense artificial sweetener taste approximately 200 times as sweet as sucrose and used as an additive in more than 6,000 products. Aspartame (APM) was submitted for pre-marketing safety evaluation in early 1980. The studies, performed by GD-Searle, produced controversial results.
UNASSIGNED: Because of the great commercial diffusion of aspartame, in 1997 the Ramazzini Institute (RI) started a large experimental project on rodents to test the carcinogenic effects of aspartame following an experimental model with more sensitive characteristics, namely a large number of rat and mice, starting treatment from prenatal life, observation until spontaneous death. Overall, the project included studying 2270 rats and 852 mice. These studies have shown that aspartame is a carcinogenic agent in experimental animals, inducing a significant dose-related increased incidence of several types of malignant tumors and, among them, hematological neoplasia, and liver cancer.
UNASSIGNED: The results of these studies on aspartame by the Ramazzini Institute opened a real front on the evaluation of artificial sweeteners and their possible health risks. Adequate long-term
carcinogenicity bioassays on other diffuse artificial sweeteners such as acesulfame-k, sucralose, saccharin, including their blends, are likewise important for public health.