Abstract：
Plasticizers are necessary for the usability of various products, including food contact materials. Exposure to plasticizers is most commonly made through the oral route. Several plasticizers have been reported to have adverse effects on humans and the environment. Thus, the present study aimed to determine the long-term toxicity and carcinogenicity of a novel plasticizer called bis(2-ethylhexyl) cyclohexane-1,4-dicarboxylate (Eco-DEHCH), which is an ecofriendly and biologically less harmful replacer. Groups of 50 male and 50 female Han Wistar rats were fed Eco-DEHCH at daily doses of 1,600, 5,000, or 16,000 ppm in their diet for at least 104 weeks. The rats were regularly monitored for mortality, clinical signs, body weight, food consumption, food efficiency, and perceivable mass. All animals were subjected to complete necropsy and histopathological examination. The results indicate that the rats well tolerated chronic exposure to Eco-DEHCH at highest daily doses of 16,000 ppm, with was equivalent to 805.1 mg/kg/day in males and 1060.6 mg/kg/day in females and did not show signs of toxicity or carcinogenicity. In conclusion, Eco-DEHCH could be a safe and promising alternative plasticizer.
摘要：
增塑剂是各种产品可用性所必需的，包括食品接触材料。暴露于增塑剂最常见的是通过口服途径。已经报道了几种增塑剂对人类和环境具有不利影响。因此，本研究旨在确定一种名为1,4-二羧酸二(2-乙基己基)环己烷(Eco-DEHCH)的新型增塑剂的长期毒性和致癌性，这是一种生态友好且生物学上危害较小的替代品。一组50只雄性和50只雌性HanWistar大鼠在其饮食中以每日1,600、5,000或16,000ppm的剂量喂养Eco-DEHCH至少104周。定期监测大鼠的死亡率，临床体征,体重,食物消费,食物效率,和可感知的质量。对所有动物进行完全尸检和组织病理学检查。结果表明，在16,000ppm的最高日剂量下，大鼠对长期暴露于Eco-DEHCH的耐受性良好，男性相当于805.1毫克/千克/天，女性相当于1,060.6毫克/千克/天，没有显示毒性或致癌性迹象。总之,Eco-DEHCH可能是一种安全且有前途的替代增塑剂。
