目的:炎症性肠病(IBD)患者更有可能被证实为维生素D缺乏。然而,炎症与维生素D之间的关联尚不清楚.这项研究的目的是评估住院IBD患者炎症与维生素D之间的关系。
方法:所有参与者于2018年6月至2022年10月从一家教学医院招募。通过血清C反应蛋白(CRP)浓度评估炎症,入院时使用免疫比浊法。我们根据血清CRP水平将参与者进一步分为五组:<5、5-9.9、10-19.9、20-39.9和>40mg/L。通过液相色谱-串联质谱法评估血清25-羟基维生素D(25-(OH)-D)。附加信息,包括年龄,性别,体重指数(BMI),IBD(溃疡性结肠炎与克罗恩病)亚型,是从医疗记录中提取出来的.
结果:这项研究包括1,989例IBD患者(平均年龄为39.4岁,其中33.8%是女性,1,365名CD和624名UC患者)。CRP中位数为5.49mg/L(四分位数范围:1.64〜19.5mg/L),25-(OH)-D缺乏症的患病率为69.8%。CRP与血清25-(OH)-D水平显著相关。25-(OH)-D的差异为-4.28ng/ml(-5.27ng/ml,-3.31ng/ml)在调整潜在协变量(年龄,性别,BMI,IBD类型,膳食类型,季节,和淋巴细胞计数)。性别亚组分析,IBD类型,和年龄,与主要分析结果相似。
结论:住院IBD患者的CRP水平与维生素D呈负相关。
OBJECTIVE: Patients with inflammatory bowel disease (IBD) are more likely to be confirmed with vitamin D deficiency. However, the association between inflammation and vitamin D remains unclear. The purpose of this study was to evaluate the association between inflammation and vitamin D in hospitalized patients with IBD.
METHODS: All the participants were recruited from one teaching hospital from June 2018 to October 2022. Inflammation was evaluated by serum concentration of C-reactive protein (CRP), using an immunoturbidimetric method at admission. We further divided the participants into five groups based on serum CRP levels: <5, 5-9.9, 10-19.9, 20-39.9, and >40mg/L. Serum 25-hydroxy-vitamin D (25-(OH)-D) was assessed by liquid chromatography tandem mass spectrometry. Addi-tional information, including age, sex, body mass index (BMI), IBD (ulcerative colitis vs. Crohn\'s disease) subtype, was abstracted from medical records.
RESULTS: This study included 1,989 patients with IBD (average age was 39.4 years, 33.8% of them were women, 1,365 CD and 624 UC patients). The median CRP was 5.49 mg/L (range of quartiles: 1.64~19.5 mg/L) and the prevalence of 25-(OH)-D deficiency was 69.8%. CRP was significantly associated with serum level of 25-(OH)-D. The difference in 25-(OH)-D was -4.28 ng/ml (-5.27 ng/ml, -3.31 ng/ml) between two extremist CRP groups after adjustment of potential covariates (age, sex, BMI, type of IBD, dietary type, season, and lymphocyte count). Subgroup analysis in sex, type of IBD, and age, were similar to the main analysis results.
CONCLUSIONS: There was a negative association between CRP levels and vitamin D in hospitalized patients with IBD.