METHODS: The study analyzed data from the 2015-2018 NHANES cycles, focusing on a nationally representative sample of individuals aged 30 years and above. Weighted multivariable negative binomial and logistic regression analyses were employed to explore the relationship between dental caries and CRP levels, adjusting for age, gender, race, education level, diabetes status, and gum disease.
RESULTS: The results of the negative binomial regression analysis demonstrated a positive association between higher CRP levels and an increased mean number of dental caries (Adjusted Mean Ratio [AMR] = 1.7; 95% CI: 1.3 - 2; P: < 0.001). The logistic regression analysis showed that individuals with higher CRP levels have a 50% increase in the odds of developing dental caries (AOR: 1.5, CI: 1.2 - 1.9; P: < 0.01).
CONCLUSIONS: The results of this cross-sectional study of the U.S. population highlight the positive association between high CRP levels and increased dental caries. These findings contribute to the growing body of evidence supporting the integration of oral and systemic health care. Further research is necessary to deepen our understanding of the mechanistic relationship between CRP levels and dental caries.
方法:该研究分析了2015-2018年NHANES周期的数据,关注30岁及以上的具有全国代表性的个人样本。采用加权多变量负二项和logistic回归分析来探讨龋齿与CRP水平之间的关系。调整年龄,性别,种族,教育水平,糖尿病状态,和牙龈疾病。
结果:负二项回归分析的结果表明,较高的CRP水平与平均龋齿数量增加之间呈正相关(调整平均比率[AMR]=1.7;95%CI:1.3-2;P:<0.001)。Logistic回归分析显示,CRP水平较高的个体患龋齿的几率增加50%(AOR:1.5,CI:1.2-1.9;P:<0.01)。
结论:这项针对美国人群的横断面研究的结果强调了高CRP水平与龋齿增加之间的正相关。这些发现有助于越来越多的证据支持口腔和全身保健的整合。需要进一步的研究以加深我们对CRP水平与龋齿之间机制关系的理解。