背景:尽管阿尔茨海默病(AD)的大脑活动可以通过MRI和PET进行评估,大脑温度(BT)之间的关系,沿血管周围空间的扩散指数(ALPS指数),和淀粉样蛋白在大脑皮层的沉积还不清楚。
目的:探讨AD患者和正常对照(NC)的代谢成像测量与临床信息之间的关系。
方法:前瞻性数据集的回顾性分析。
方法:58名参与者(78.3±6.8岁;30名女性):来自开放获取系列成像研究数据集的29名AD患者和29名年龄和性别匹配的NCs。
■3T;T1-加权磁化-制备的快速梯度回波,64个方向的扩散张量成像,和动态18F-florbetapirPET。
结果:比较了AD和NC的影像学指标。这些包括通过侧脑室的扩散率计算的BT,反映淋巴系统的ALPS指数,大脑皮层淀粉样蛋白PET的平均标准化摄取值比率(SUVR)和临床信息,比如年龄,性别,和MMSE。
方法:Pearson或Spearman的相关和多元线性回归分析。P值<0.05被定义为具有统计学意义。
结果:发现BT和ALPS指数之间存在显著正相关(对于NC,r=0.44),年龄与ALPS指数呈显著负相关(rs=-0.43,NCs=-0.47)。淀粉样蛋白PET的SUVR与BT(AD的P=0.81,NC的P=0.21)或ALPS指数(AD的P=0.10,NC的P=0.52)没有显着相关。在多元回归分析中,年龄与BT显著相关,而年龄,性别,AD的存在与ALPS指数显著相关。
结论:使用MRI测量的淋巴系统受损与较低的BT和衰老相关。
方法:3技术效率阶段:1.
BACKGROUND: Although brain activities in Alzheimer\'s disease (AD) might be evaluated MRI and PET, the relationships between brain temperature (BT), the index of diffusivity along the perivascular space (ALPS index), and amyloid deposition in the cerebral cortex are still unclear.
OBJECTIVE: To investigate the relationship between metabolic imaging measurements and clinical information in patients with AD and normal controls (NCs).
METHODS: Retrospective analysis of a prospective dataset.
METHODS: 58 participants (78.3 ± 6.8 years; 30 female): 29 AD patients and 29 age- and sex-matched NCs from the Open Access Series of Imaging Studies dataset.
UNASSIGNED: 3T; T1-weighted magnetization-prepared rapid gradient-echo, diffusion tensor imaging with 64 directions, and dynamic 18 F-florbetapir PET.
RESULTS: Imaging metrics were compared between AD and NCs. These included BT calculated by the diffusivity of the lateral ventricles, ALPS index that reflects the glymphatic system, the mean standardized uptake value ratio (SUVR) of amyloid PET in the cerebral cortex and clinical information, such as age, sex, and MMSE.
METHODS: Pearson\'s or Spearman\'s correlation and multiple linear regression analyses. P values <0.05 were defined as statistically significant.
RESULTS: Significant positive correlations were found between BT and ALPS index (r = 0.44 for NCs), while significant negative correlations were found between age and ALPS index (rs = -0.43 for AD and - 0.47 for NCs). The SUVR of amyloid PET was not significantly associated with BT (P = 0.81 for AD and 0.21 for NCs) or ALPS index (P = 0.10 for AD and 0.52 for NCs). In the multiple regression analysis, age was significantly associated with BT, while age, sex, and presence of AD were significantly associated with the ALPS index.
CONCLUSIONS: Impairment of the glymphatic system measured using MRI was associated with lower BT and aging.
METHODS: 3 TECHNICAL EFFICACY STAGE: 1.