Abstract：
We present here the initial development of a novel algorithm based on broadband near-infrared spectroscopy (bNIRS) data to estimate the changes in brain temperature (BT) in neonates. We first explored the validity of the methodology on a simple numerical phantom and reported good agreements between the theoretical and retrieved values of BT and hemodynamic parameters changes, which are the parameters usually targeted by bNIRS. However, we noted an underestimation of the absolute values of temperature and haemoglobins\' concentration changes when large variations of tissue saturation were induced, probably due to a crosstalk between the species in this specific case. We then tested this methodology on data acquired on 2 piglets during a protocol that induces seizures. We showed that despite a decrease in rectal temperature (RT) over time (-0.1048 °C 1.5 h after seizure induction, 95% CI: -0.1035 to -0.1061 °C), BT was raising (0.3122 °C 1.5 h after seizure induction, 95% CI: 0.3207 to 0.3237 °C). We also noted that the piglet displaying the largest decrease in RT also displays the highest increase in BT, which could be a marker of the severity of the seizure induced brain injury. These initial results are encouraging and show that having access to the changes in BT non-invasively could help to better understand the impact of BT on injury severity and to improve the current cooling methodologies in the neonatal neurocritical care following neonatal encephalopathy.
摘要：
我们在这里介绍了一种基于宽带近红外光谱（bNIRS）数据的新型算法的初步开发，以估计新生儿大脑温度（BT）的变化。我们首先在一个简单的数字模型上探索了该方法的有效性，并报道了BT和血液动力学参数变化的理论值和检索值之间的良好一致性。这是bNIRS通常针对的参数。然而,我们注意到，当引起组织饱和度的大变化时，温度和血红蛋白浓度变化的绝对值被低估，可能是由于在这种特定情况下物种之间的串扰。然后，我们在诱导癫痫发作的方案中对2只仔猪获得的数据进行了这种方法的测试。我们表明，尽管直肠温度（RT）随着时间的推移而降低（癫痫发作诱导后-0.1048°C1.5小时，95%CI：-0.1035至-0.1061°C），BT升高（癫痫发作诱导后0.3122°C1.5小时，95%CI：0.3207至0.3237°C）。我们还注意到，RT下降幅度最大的仔猪也表现出BT的最高增长，这可能是癫痫诱发脑损伤严重程度的标志。这些初步结果令人鼓舞，并表明非侵入性获得BT的变化可以帮助更好地了解BT对损伤严重程度的影响，并改善新生儿脑病后新生儿神经重症监护中当前的降温方法。
