背景:微藻,如三角皮指藻(PT)含有类胡萝卜素,岩藻黄质,据说是为了促进脂肪流失,降低血脂,改善血糖管理。这项研究检查了饮食中含有4.4mg/d岩藻黄质的PT微藻提取物是否会影响运动和饮食干预期间超重女性的身体成分或健康标志物的变化。
方法:共有37名女性(28.6±7.9岁,80.2±14.9kg,29.6±3.8kg/m²,41.4±4.2%脂肪)禁食12小时,捐献了一份空腹血液样本,完成健康和情绪状态清单,并进行了身体成分,健康,和运动评估。在一个平衡的,随机化,双盲的方式,参与者摄入安慰剂(PL),或三头Phaeodactylum的微藻提取物标准化为4.4mg岩藻黄质(FX),持续12周,同时参加有监督的运动计划,其中包括阻力训练和步行(3天/周),并鼓励每天累积10,000步一周的剩余天数。饮食干预涉及将能量摄入减少约-300千卡/天(即,约1400-1600kcals/d,55%碳水化合物,30%脂肪,15%的蛋白质)通过运动促进a-500kcal/d的能量不足。在6周和12周进行随访测试。使用具有重复测量统计分析的一般线性模型(GLM)以95%置信区间分析组反应和从基线的变化。
结果:饮食补充含有岩藻黄质的PT微藻提取物12周并不能促进超重的额外体重减轻或脂肪减少,但健康女性开始运动和饮食干预旨在促进适度体重减轻。然而,岩藻黄质补充保存的骨量,骨密度增加,并在步行步数/日上看到了更大的改善,静息心率,有氧能力,血脂谱,坚持饮食目标,功能活性耐受性,和生活质量的衡量标准。因此,在饮食和锻炼计划中补充含有岩藻黄质的PT微藻提取物似乎有一些好处。注册临床试验#NCT04761406。
BACKGROUND: Microalgae like Phaeodactylum tricornutum (PT) contain the carotenoid, fucoxanthin, which has been purported to promote fat loss, lower blood lipids, and improve glucose management. This study examined whether dietary supplementation with microalgae extracts from PT containing 4.4 mg/d of fucoxanthin affects changes in body composition or health markers in overweight women during an exercise and diet intervention.
METHODS: A total of 37 females (28.6 ± 7.9 years, 80.2 ± 14.9 kg, 29.6 ± 3.8 kg/m², 41.4 ± 4.2% fat) fasted for 12 h, donated a fasting blood sample, completed health and mood state inventories, and undertook body composition, health, and exercise assessments. In a counterbalanced, randomized, and double-blind manner, participants ingested a placebo (PL), or microalgae extract of Phaeodactylum tricornutum standardized to 4.4 mg of fucoxanthin (FX) for 12 weeks while participating in a supervised exercise program that included resistance-training and walking (3 days/week) with encouragement to accumulate 10,000 steps/day on remaining days of the week. The diet intervention involved reducing energy intake by about -300 kcal/d (i.e., ≈1400-1600 kcals/d, 55% carbohydrate, 30% fat, 15% protein) to promote a -500 kcal/d energy deficit with exercise. Follow-up testing was performed at 6 and 12 weeks. A general linear model (GLM) with repeated measures statistical analysis was used to analyze group responses and changes from baseline with 95% confidence intervals.
RESULTS: Dietary supplementation with microalgae extract from PT containing fucoxanthin for 12 weeks did not promote additional weight loss or fat loss in overweight but otherwise healthy females initiating an exercise and diet intervention designed to promote modest weight loss. However, fucoxanthin supplementation preserved bone mass, increased bone density, and saw greater improvements in walking steps/day, resting heart rate, aerobic capacity, blood lipid profiles, adherence to diet goals, functional activity tolerance, and measures of quality of life. Consequently, there appears to be some benefit to supplementing microalgae extract from PT containing fucoxanthin during a diet and exercise program. Registered clinical trial #NCT04761406.