PDF(Pubmed)
Abstract：
Time-restricted eating (TRE) has emerged as a dietary strategy that restricts food consumption to a specific time window and is commonly applied to facilitate weight loss. The benefits of TRE on adipose tissue have been evidenced in human trials and animal models; however, its impact on bone tissue remains unclear. To systematically synthesize and examine the evidence on the impact of TRE on bone health (bone mineral content (BMC), bone mineral density (BMD), and bone turnover factors), PubMed, Scopus, Cochrane CENTRAL, and Web of Science databases were systematically explored from inception to 1 October 2023 searching for randomized controlled trials (RCTs) aimed at determining the effects of TRE on bone health in adults (≥18 years). The Cochrane Handbook and the PRISMA recommendations were followed. A total of seven RCTs involving 313 participants (19 to 68 years) were included, with an average length of 10.5 weeks (range: 4 to 24 weeks). Despite the significant weight loss reported in five out of seven studies when compared to the control, our meta-analysis showed no significant difference in BMD (g/cm2) between groups (MD = -0.009, 95% CI: -0.026 to 0.009, p = 0.328; I2 = 0%). BMC and bone turnover markers between TRE interventions and control conditions were not meta-analyzed because of scarcity of studies (less than five). Despite its short-term benefits on cardiometabolic health, TRE did not show detrimental effects on bone health outcomes compared to those in the control group. Nevertheless, caution should be taken when interpreting our results due to the scarcity of RCTs adequately powered to assess changes in bone outcomes.
摘要：
限时饮食（TRE）已成为一种饮食策略，将食物消耗限制在特定的时间范围内，通常用于促进体重减轻。在人体试验和动物模型中已经证明了TRE对脂肪组织的益处；然而，其对骨组织的影响尚不清楚。为了系统地综合和检查TRE对骨健康影响的证据(骨矿物质含量(BMC)，骨矿物质密度（BMD），和骨转换因素)，PubMed,Scopus,科克伦中部,和WebofScience数据库从开始到2023年10月1日进行了系统探索,寻找旨在确定TRE对成人(≥18岁)骨骼健康影响的随机对照试验(RCT).遵循了Cochrane手册和PRISMA建议。共纳入7项RCT，涉及313名参与者（19至68岁），平均长度为10.5周（范围：4至24周）。尽管与对照组相比，七项研究中有五项报道了显着的体重减轻，我们的荟萃分析显示,组间BMD(g/cm2)无显著差异(MD=-0.009,95%CI:-0.026~0.009,p=0.328;I2=0%).由于缺乏研究（少于5项），未对TRE干预措施和对照条件之间的BMC和骨转换标志物进行荟萃分析。尽管它对心脏代谢健康有短期益处，与对照组相比，TRE对骨骼健康结果没有不利影响。然而，由于缺乏足够的RCT来评估骨骼结果的变化，因此在解释我们的结果时应谨慎。
