■鉴于波多黎各和更广泛的美国普遍存在的肥胖和糖尿病问题,迫切需要调查BMI之间复杂的相互作用,孕前,和妊娠期糖尿病,以及它们对新生儿发育过程中先天性心脏病(CHD)发生的潜在影响。
■使用波多黎各先天性缺陷的全面警戒和监测系统,我们对2016-2020年诊断为冠心病的新生儿进行了重点分析.我们的评估包括一系列变量,包括产妇年龄,胎龄,BMI,孕前糖尿病,妊娠期糖尿病,高血压,流产史,和先兆子痫的存在。
■我们的研究包括673名患者。产妇平均年龄26岁,在22到32年的范围内。平均胎龄测量为39周,中位跨度为38至39周。在673名患者中,274名(41%)母亲生下了被诊断为冠心病的新生儿。在这个群体中,22例与孕前糖尿病有关,而202则没有;20例与妊娠糖尿病有关,与200例没有;148例表现出超重或肥胖的BMI,而126显示正常的BMI。
■我们确定了孕前糖尿病与CHD发生之间的统计学显着相关性。然而,我们的分析未显示孕妇BMI与CHD可能性之间存在统计学显著关联.这些结果可能有助于制定有效的策略来预防和管理新生儿CHD。
UNASSIGNED: Given the pervasive issues of obesity and diabetes both in Puerto Rico and the broader United States, there is a compelling need to investigate the intricate interplay among BMI, pregestational, and gestational maternal diabetes, and their potential impact on the occurrence of congenital heart defects (CHD) during neonatal development.
UNASSIGNED: Using the comprehensive System of Vigilance and Surveillance of Congenital Defects in Puerto Rico, we conducted a focused analysis on neonates diagnosed with CHD between 2016 and 2020. Our assessment encompassed a range of variables, including maternal age, gestational age, BMI, pregestational diabetes, gestational diabetes, hypertension, history of abortion, and presence of preeclampsia.
UNASSIGNED: A cohort of 673 patients was included in our study. The average maternal age was 26 years, within a range of 22 to 32 years. The mean gestational age measured 39 weeks, with a median span of 38 to 39 weeks. Of the 673 patients, 274 (41%) mothers gave birth to neonates diagnosed with CHD. Within this group, 22 cases were linked to pre-gestational diabetes, while 202 were not; 20 instances were associated with gestational diabetes, compared to 200 without; and 148 cases exhibited an overweight or obese BMI, whereas 126 displayed a normal BMI.
UNASSIGNED: We identified a statistically significant correlation between pre-gestational diabetes mellitus and the occurrence of CHD. However, our analysis did not show a statistically significant association between maternal BMI and the likelihood of CHD. These results may aid in developing effective strategies to prevent and manage CHD in neonates.