普鲁兰,一种具有独特生物相容性和生物降解性的天然多糖,在纳米医学中获得了突出的地位。其在纳米颗粒药物递送系统中的应用展示了其在精准医学中的潜力。
目的:本科学综述旨在全面讨论和总结基于支链淀粉的聚合物纳米颗粒的最新进展,专注于他们的配方,表征,评估,和功效。
方法:在Scopus上搜索,PubMed,和谷歌学者,使用“普鲁兰和纳米粒子”作为关键字,近年来发现了相关文章。
结果:文献检索突出了关于普鲁兰多糖基聚合物纳米粒子的各种研究,包括成功的高选择性混合支链淀粉为基础的纳米颗粒用于有效的硼在结肠癌的靶向纳米颗粒,hyalgan包被的基于普鲁兰的纳米颗粒的开发的特异性和高效的释放曲线,以及多功能微针贴片的设计,该贴片掺入了基于支链淀粉-胶原蛋白的纳米颗粒负载的抗微生物剂以加速伤口愈合。这些研究共同强调了基于支链淀粉的聚合物纳米颗粒在解决生物医学挑战方面的多功能性和变革潜力。
结论:基于Pullulan的聚合物纳米颗粒是创新药物递送系统的有希望的候选药物,有可能克服与传统递送方法相关的限制。
Pullulan, a natural polysaccharide with unique biocompatibility and biodegradability, has gained prominence in nanomedicine. Its application in nanoparticle drug delivery systems showcases its potential for precision medicine.
OBJECTIVE: This scientific review aims to comprehensively discuss and summarize recent advancements in pullulan-based polymeric nanoparticles, focusing on their formulation, characterization, evaluation, and efficacy.
METHODS: A search on Scopus, PubMed, and Google Scholar, using \"Pullulan and Nanoparticle\" as keywords, identified relevant articles in recent years.
RESULTS: The literature search highlighted a diverse range of studies on the pullulan-based polymeric nanoparticles, including the success of high-selectivity hybrid pullulan-based nanoparticles for efficient boron delivery in colon cancer as the active targeting nanoparticle, the specific and high-efficiency release profile of the development of hyalgan-coated pullulan-based nanoparticles, and the design of multifunctional microneedle patches that incorporated pullulan-collagen-based nanoparticle-loaded antimicrobials to accelerate wound healing. These studies collectively underscore the versatility and transformative potential of pullulan-based polymeric nanoparticles in addressing biomedical challenges.
CONCLUSIONS: Pullulan-based polymeric nanoparticles are promising candidates for innovative drug delivery systems, with the potential to overcome the limitations associated with traditional delivery methods.