关键词: Action mechanism Antimicrobial activity Biopolymer Chitin Chitosan Influencing factors

Mesh : Chitosan / chemistry pharmacology Anti-Infective Agents / pharmacology chemistry Anti-Bacterial Agents / pharmacology chemistry Fungi / drug effects Bacteria / drug effects Humans

来  源:   DOI:10.1016/j.ijbiomac.2024.134321

Abstract:
Chitosan, a versatile amino polysaccharide biopolymer derived from chitin, exhibits broad-spectrum antimicrobial activity against various pathogenic microorganisms, including gram-negative and gram-positive bacteria, as well as fungi. Due to its ubiquitous use in medications, food, cosmetics, chemicals, and crops, it is an effective antibacterial agent. However, the antimicrobial performance of chitosan is influenced by multiple factors, which have been extensively investigated and reported in the literature. The goal of this review paper is to present a thorough grasp of the mechanisms of action and determining variables of chitosan and its derivatives\' antibacterial activity. The article begins by providing a brief background on chitosan and its antimicrobial properties, followed by the importance of understanding the mechanism of action and factors influencing its activity\".
摘要:
壳聚糖,一种源自几丁质的多功能氨基多糖生物聚合物,对各种病原微生物具有广谱抗微生物活性,包括革兰氏阴性菌和革兰氏阳性菌,以及真菌。由于它在药物中无处不在,食物,化妆品,化学品,和庄稼,它是一种有效的抗菌剂。然而,壳聚糖的抗菌性能受多种因素的影响,在文献中进行了广泛的研究和报道。这篇综述论文的目的是全面掌握壳聚糖及其衍生物的作用机制和确定变量的抗菌活性。本文首先提供了壳聚糖及其抗菌性能的简要背景,其次是了解作用机制和影响其活性的因素的重要性。“
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