biomedical research

生物医学研究
  • 文章类型: Editorial
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  • 文章类型: Journal Article
    医学科学必须基于可靠和科学的证据,并需要持续的研究。从事研究可以让学生和教师探索新的领域,质疑现有的范式,并发现医疗挑战的创新解决方案。作为特产,社区医学在解决公共卫生问题方面发挥着关键作用。然而,社区医学居民在生物医学研究中的参与度仍然欠佳,这可能会阻碍针对印度背景的循证实践的产生。这项研究是为了寻找社区医学居民的兴趣和参与度,以及影响他们对生物医学研究兴趣的因素。方法对北方邦社区医疗居民进行在线调查,从2024年2月到4月,使用具有半结构化的GoogleForms,预先测试的问卷。结果一百九十六名居民参与研究,其中女性(52.6%;103/196)超过男性(47.4%;93/196)。大多数参与者是三年级居民(40.8%)。大多数参与者似乎对生物医学研究感兴趣(83.2%),并认为生物医学研究基础课程(BCBR)有助于开展研究项目(75%)。大约一半的人以前有研究项目的经验,横断面研究是最常见的(75.9%)研究设计。提高研究技能和为医学知识做出贡献的愿望成为主要动力。另一方面,由于学术和教育活动负担过重而缺乏时间被视为进行研究的最常见障碍。结论发现大多数参与者对研究活动感兴趣。提高研究技能的机会,渴望为医疗兄弟会服务,对简历的积极影响是进行研究的主要激励因素。难以节省时间,小知识,导师的不良支持被认为是重要的障碍。
    Introduction Medical science must be based on sound and scientific evidence and requires continuous research. Engaging in research allows students and faculty to explore new frontiers, question existing paradigms, and discover innovative solutions to medical challenges. As a specialty, community medicine plays a pivotal role in addressing public health issues. However, the engagement of community medicine residents in biomedical research remains suboptimal, which may impede the generation of evidence-based practices tailored to the Indian context. This study was conducted to find the interest and engagement of community medicine residents, and factors influencing their interest in biomedical research. Methods An online survey was conducted among community medicine residents of Uttar Pradesh, from February to April 2024, using Google Forms having a semi-structured, pretested questionnaire. Results One hundred and ninety-six residents participated in the study, where females (52.6%; 103/196) outnumbered males (47.4%; 93/196). The majority of participants were third-year residents (40.8%). Most participants seemed interested in biomedical research (83.2%) and thought that Basic Course in Biomedical Research (BCBR) helps conduct research projects (75%). Around half had previous experience in research projects, with cross-sectional studies being the most common (75.9%) study design. Enhancing research skills and a desire to contribute to medical knowledge emerged as primary motivators. On the other hand, the lack of time due to being overburdened with academic and educational activities was seen as the most common barrier to conducting research. Conclusions The majority of participants were found interested in research activities. The opportunity to improve research skills, desire to serve the medical fraternity, and a positive impact on resumes were the leading motivating factors for conducting research. Difficulty in sparing time, little knowledge, and poor support from mentors were found as important barriers.
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  • 文章类型: Journal Article
    背景:在临床研究中使用患者报告的结果指标(PROMs)增加,异构仪器的使用反映了医学专业如何很好地捕获不同的特征。为了反映当前PROM在眼科中使用的异质性,我们回顾了现有的文献。
    方法:在医学文献数据库WebofScience中搜索了临床眼科中引用最多的文章。标题,对使用PROM的摘要和全文文章进行了审查,并获得了使用PROM引用最多的100篇文章的列表,并按出版年份进行了分层。
    结果:共筛选了1,996篇文章。在确定的100篇文章中,有77篇文章包括一篇PROM,仪器平均数量为1.5±1.1。最广泛使用的PROM是国家眼科研究所的视觉功能问卷(33%),眼表疾病指数(14%)和医学结果研究简短形式(13%)。模拟分析表明,眼科研究中PROM的使用分布与幂律分布没有显着差异。22%和15%的文章没有引用,也没有说明使用的PROM,分别。这一比率在最近发表的文章中有所下降(p=0.041)。
    结论:我们的数据表明,应用于眼科研究的PROM的异质性较低。临床研究的PROM的选择应谨慎,取决于研究目标。
    BACKGROUND: The use of patient-reported outcome measures (PROMs) in clinical research increases and use of heterogeneous instruments reflects how well diverse traits are captured by a medical specialty. In order to reflect the heterogeneity of current PROM use in ophthalmology, we reviewed the available literature.
    METHODS: The medical literature database Web of Science was searched for the most cited articles in clinical ophthalmology. Titles, abstracts and full text articles were reviewed for the use of PROMs and a list of the 100 most cited articles using PROMs was obtained and stratified by year of publication.
    RESULTS: A total of 1,996 articles were screened. Seventy-seven out of the 100 articles identified included one PROM, and the average number of instruments was 1.5 ± 1.1. The most widely used PROMs were the National Eye Institute Visual Function Questionnaire (33%), the Ocular Surface Disease Index (14%) and the Medical Outcomes Study Short Form (13%). A simulation analysis suggested that the distribution of PROM use in ophthalmology study did not significantly differ from a power law distribution. Twenty-two percent and fifteen percent of articles did not reference and did not specify the PROM used, respectively. This rate decreased in the more recently published articles (p = 0.041).
    CONCLUSIONS: Our data suggest that the heterogeneity of PROMs applied in ophthalmology studies is low. The selection of PROMs for clinical studies should be done carefully, depending on the research goal.
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  • 文章类型: Journal Article
    背景:尽管混合方法在健康研究中具有核心作用,评估健康科学在线方法培训的研究是不存在的。重点目标是通过将经历过面对面撤退的学者的自我评估技能与2015-2023年在健康科学混合方法研究特定领域的在线撤退中的学者进行比较来评估在线培训。
    方法:作者根据教育能力量表管理了学者混合方法技能自我评估工具,其中包括以下领域:“研究问题,“\”设计/方法,\"\"取样,\"\"分析,“和”传播“健康科学混合方法研究培训计划(MMRTP)的参与者。在亲自参加(n=73)或在线参加(n=57)的队列中撤退参与之前和之后,比较了对领域的信心的自我评分,并比较了面对面与在线队列的差异。分析了对有关撤退经验的开放式问题的回答。
    结果:提高混合方法技能的互动计划中的学者报告说,他们对定义或解释概念的能力以及将概念应用于实际问题的能力的信心显着增强,该计划是亲自参加还是在线同步参加。在线务虚会中的学者自我评价的技能进步与亲自参加的学者一样好或更好。除了网络之外,学者们发现,在线格式与可访问性,减轻旅行负担和寻找托儿服务等优势有关。没有描述学习概念的难度差异。
    结论:记住撤退只是MMRTP的一个组成部分,这项研究提供的证据表明,在线混合方法培训与在线参与者的自评技能的增加相同,并且可以成为提高健康科学中混合方法研究能力的关键组成部分.
    BACKGROUND: Despite the central role of mixed methods in health research, studies evaluating online methods training in the health sciences are nonexistent. The focused goal was to evaluate online training by comparing the self-rated skills of scholars who experienced an in-person retreat to scholars in an online retreat in specific domains of mixed methods research for the health sciences from 2015-2023.
    METHODS: The authors administered a scholar Mixed Methods Skills Self-Assessment instrument based on an educational competency scale that included domains on: \"research questions,\" \"design/approach,\" \"sampling,\" \"analysis,\" and \"dissemination\" to participants of the Mixed Methods Research Training Program for the Health Sciences (MMRTP). Self-ratings on confidence on domains were compared before and after retreat participation within cohorts who attended in person (n = 73) or online (n = 57) as well as comparing across in-person to online cohorts. Responses to open-ended questions about experiences with the retreat were analyzed.
    RESULTS: Scholars in an interactive program to improve mixed methods skills reported significantly increased confidence in ability to define or explain concepts and in ability to apply the concepts to practical problems, whether the program was attended in-person or synchronously online. Scholars in the online retreat had self-rated skill improvements as good or better than scholars who participated in person. With the possible exception of networking, scholars found the online format was associated with advantages such as accessibility and reduced burden of travel and finding childcare. No differences in difficulty of learning concepts was described.
    CONCLUSIONS: Keeping in mind that the retreat is only one component of the MMRTP, this study provides evidence that mixed methods training online was associated with the same increases in self-rated skills as persons attending online and can be a key component to increasing the capacity for mixed methods research in the health sciences.
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  • 文章类型: Journal Article
    目的:本研究的目的是确定接受资助的骨科创伤住院医师研究项目的发表率和资助接受者的长期学术参与。
    方法:
    方法:回顾性分析。
    方法:居民研究补助金接受者的公开记录。
    骨科创伤协会(OTA)关于骨科创伤主题的居民研究资助,AO北美(AONA),以及2000年至2022年的骨科研究和教育基金会。
    后续相关出版物,赠款大小,出版时间,以学术地位衡量的居民的持续学术参与,出版物总数,和h-index。
    结果:确定了三百九十七项骨科创伤补助金(OTA117、AONA225和OREF55)。共有38%(151)的赠款导致出版物在机构之间没有显着差异(P=0.94)。授予的平均金额为9,843美元,与出版物无关(P=0.63)。平均出版时间为3.57±2.33年。AONA的发布时间明显长于OTA(4.14vs.2.83年,P=0.004)。总出版物没有差异,h-index,或来自不同机构的赠款接受者之间的NIH赠款。与AONA赠款接受者相比,更多的OTA赠款接受者担任学术职位(63%与43%,P=0.003)。最初出版成功的授予获奖者是未来学术任命的1.7倍(P=0.014),出版物数量是没有出版物的1.9倍(P=0.001)。h指数在前四分位数的获奖者比h指数在后四分位数的获奖者更有可能发表(P=0.007)。
    结论:不到一半的骨科创伤相关居民研究资助导致了一份机构间具有可比性的出版物。授予大小无法预测发布成功。出版成功是持续学术参与的积极预测因素。大多数出版物发生在5年内,这表明,如果在5年骨科住院医师计划的前1-2年内授予,这些补助金可能对职业发展最有帮助。
    OBJECTIVE: The objective of this study was to determine the publication rate for orthopaedic trauma resident research projects that receive grant funding and the long-term academic involvement of the grant recipients.
    METHODS:
    METHODS: Retrospective.
    METHODS: Publically available records for resident research grant recipients.
    UNASSIGNED: Resident research grants on orthopaedic trauma topics from Orthopaedic Trauma Association (OTA), AO North America (AONA), and Orthopaedic Research and Education Foundation from 2000 to 2022.
    UNASSIGNED: Subsequent related publications, grant size, time to publication, sustained academic involvement of the residents as measured by academic position, total number of publications, and h-index.
    RESULTS: Three hundred ninety-seven orthopaedic trauma grants (OTA 117, AONA 225, and OREF 55) were identified. A total of 38% (151) of grants resulted in a publication with no significant difference between agencies (P = 0.94). The average amount awarded was $9,843, with no correlation to publication (P = 0.63). The mean time to publication was 3.57 ± 2.33 years. The time to publication for AONA was significantly longer than for OTA (4.14 vs. 2.83 years, P = 0.004). There was no difference in total publications, h-index, or NIH grants between grant recipients from different agencies. More OTA grant recipients held an academic position compared with AONA grant recipients (63% vs. 43%, P = 0.003). Grant awardees with initial publication success were 1.7 times as likely to have a future academic appointment (P = 0.014) and had 1.9 times the number of publications than those without (P = 0.001). Awardees with an h-index in the top quartile were significantly more likely to have published than those with an h-index in the bottom quartile (P = 0.007).
    CONCLUSIONS: Fewer than half of orthopaedic trauma-related resident research grants resulted in a publication with comparable rates across agencies. Grant size did not predict publication success. Publication success was a positive predictor of continued academic involvement. Most publications occurred within 5 years, suggesting that these grants may be most helpful in career development if awarded during the first 1-2 years of a 5-year orthopaedic residency program.
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  • 文章类型: Historical Article
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