本研究旨在确定非洲未接种疫苗的后院家禽中新城疫的患病率。使用PRISMA方法,我们对107项流行病学研究进行了系统评价和荟萃分析.荟萃分析确定了本综述所报道的各种研究中血清阳性率(I2=99.38,P=0.00)和新城疫病毒患病率(I2=99.52,P=0.00)的显着变化。在这两种情况下均未检测到发表偏倚。新城疫的血清阳性率为40.2(95CI32.9-47.8)。血清阳性率受到采样框架和进行研究的非洲地区的显着影响。新城疫病毒(NDV)的患病率为12%(95CI7.3-17.8),变化受采样框架的影响,诊断测试,以及进行研究的地区。此外,新城疫(ND)占病鸡的33.1%(95CI11.9-58.1)。结果还表明,基因型VI和VII广泛分布在研究中包括的所有国家。然而,基因型V在东非受到限制,和基因型XIV,XVII,和十八限制在西非和中非。另一方面,基因型XI仅发生在马达加斯加。此外,从明显健康和生病的鸟类中分离出毒力基因型。结论是,NDV的几种基因型在家禽种群中循环和维持。因此,非洲国家应加强监测系统,能够研究在他们领土上传播的病毒,并建立控制程序。
The present study intended to determine the prevalence of Newcastle disease in unvaccinated backyard poultry in Africa. Using the PRISMA approach, a systematic review and meta-analysis of 107 epidemiological studies was conducted. The meta-analysis identified significant variation of both seroprevalence (I2 = 99.38, P = 0.00) and Newcastle disease virus prevalence (I2 = 99.52, P = 0.00) reported in various studies included in this review. Publication bias was not detected in either case. Seroprevalence of Newcastle disease was 40.2 (95%CI 32.9-47.8). Seroprevalence was significantly influenced by sampling frame and the African region where the studies were conducted. The prevalence of Newcastle disease virus (NDV) was 12% (95%CI 7.3-17.8), and the variation was influenced by sampling frame, diagnostic test, and regions where the studies were conducted. Also, Newcastle disease (ND) accounted for 33.1% (95%CI 11.9-58.1) of sick chickens. Results also indicated that genotypes VI and VII are widely distributed in all countries included in the study. However, genotype V is restricted in East Africa, and genotypes XIV, XVII, and XVIII are restricted in West and Central Africa. On the other hand, genotype XI occurs in Madagascar only. In addition, virulent genotypes were isolated from apparently healthy and sick birds. It is concluded that several genotypes of NDV are circulating and maintained within the poultry population. African countries should therefore strengthen surveillance systems, be able to study the viruses circulating in their territories, and establish control programs.