PDF(Pubmed)
Abstract：
In the winter of 2010-2011, Japan experienced a large outbreak of infections caused by clade 2.3.2.1 H5N1 high pathogenicity avian influenza viruses (HPAIVs) in wild birds. Interestingly, many tufted ducks (Aythya fuligula), which are migratory diving ducks, succumbed to the infection, whereas only one infection case was reported in migratory dabbling duck species, the major natural hosts of the influenza A virus, during the outbreak. To assess whether the susceptibility of each duck species to HPAIVs was correlated with the number of cases, tufted duck and dabbling duck species (Eurasian wigeon, Mareca penelope; mallard, Anas platyrhynchos; Northern pintail, Anas acuta) were intranasally inoculated with A/Mandarin duck/Miyazaki/22M807-1/2011 (H5N1), an index clade 2.3.2.1 virus previously used for experimental infection studies in various bird species. All ducks observed for 10 days post-inoculation (dpi) mostly shed the virus via the oral route and survived. The tufted ducks shed a higher titer of the virus than the other dabbling duck species, and one of them showed apparent neurological symptoms after 7 dpi, which were accompanied by eye lesions. No clinical symptoms were observed in the dabbling ducks, although systemic infection and viremia were observed in some of them sacrificed at 3 dpi. These results suggest that the susceptibility of clade 2.3.2.1 HPAIVs might differ by duck species.
摘要：
在2010-2011年冬季，日本在野生鸟类中爆发了由进化枝2.3.2.1H5N1高致病性禽流感病毒（HPAIV）引起的大规模感染。有趣的是,许多簇绒鸭（Aythyafuligula），它们是迁徙潜水鸭，死于感染,而迁徙涉猎鸭只报告了一例感染病例，甲型流感病毒的主要自然宿主，在爆发期间。为了评估每种鸭种对HPAIV的易感性是否与病例数相关，簇绒鸭和涉猎鸭物种(欧亚wigeon，马里卡·佩内洛普；野鸭，Anasplatyrhynchos；北方平尾，Anasacuta）鼻内接种A/普通话/宫崎/22M807-1/2011（H5N1），一种索引进化枝2.3.2.1病毒，以前用于各种鸟类的实验性感染研究。接种后(dpi)10天观察到的所有鸭子大多通过口服途径脱离病毒并存活。簇绒鸭的病毒滴度比其他涉猎鸭更高，其中一个在7dpi后表现出明显的神经症状，伴有眼部病变。在涉猎的鸭子中没有观察到临床症状，尽管在3dpi时处死的一些患者中观察到全身性感染和病毒血症。这些结果表明，进化枝2.3.2.1HPAIV的易感性可能因鸭种而异。
