■常见的非典型抗精神病药包括利培酮,帕潘立酮,奥氮平,Lurasidone,喹硫平,氯氮平,阿立哌唑,齐拉西酮,阿塞那平,布立哌唑,还有卡利拉嗪.以往关于抗精神病药物眼部不良反应的研究主要集中在典型的抗精神病药物。关于非典型抗精神病药的系统研究仍然有限。
■本研究旨在通过挖掘食品和药物管理局不良事件报告系统(FAERS)数据库来评估不同非典型抗精神病药引起眼部副作用的潜在风险。
■获得了FAERS从2016年第一季度到2022年第四季度的摘录报告。使用报告赔率比(ROR)方法和药品和保健产品监管机构(MHRA)方法进行与非典型抗精神病药相关的眼部疾病的数据挖掘,以确定阳性信号。
■FAERS报告包括在这28个季度中的9913783例病例。根据高级组术语(HLGT)将64例定义的眼部不良事件分为10类。
■与非典型抗精神病药相关的眼部相关不良事件的类型和严重程度存在差异。在所有11种非典型抗精神病药物中发现了与眼部神经肌肉相关的不良事件。奥氮平在眼病中的信号强度最高。阿立哌唑在眼睑痉挛中的信号强度最高。Cariprazine与白内障相关的眼部不良反应有关。就不良事件的类型而言,我们的研究发现,阿立哌唑与28种眼部不良事件有关,其次是喹硫平。氯氮平仅与两种类型的眼部不良事件相关。
UNASSIGNED: Common atypical antipsychotics include risperidone, paliperidone, olanzapine, lurasidone, quetiapine, clozapine, aripiprazole, ziprasidone, asenapine, brexpiprazole, and cariprazine. Previous studies on ocular adverse reactions of antipsychotics were mainly focused on typical antipsychotics. Systematic research on atypical antipsychotics remains limited.
UNASSIGNED: This study aimed to evaluate the potential risks of different atypical antipsychotics causing ocular side effects by mining the Food and Drug Administration Adverse Event Reporting System (FAERS) database.
UNASSIGNED: Extract reports from the FAERS from the first quarter of 2016 to the fourth quarter of 2022 were obtained. Data mining of eye disorders associated with atypical antipsychotics was carried out using The Reporting Odds Ratio (ROR) method and The Medicines and Healthcare Products Regulatory Agency (MHRA) method to determine positive signals.
UNASSIGNED: FAERS reports for 9913783 cases were included in these 28 quarters. 64 defined ocular adverse events were classified into 10 categories according to High-Level Group Terms (HLGT).
UNASSIGNED: There were differences in the types and severity of ocular-related adverse events associated with atypical antipsychotics. Ocular neuromuscular-related adverse events were found among all 11 atypical antipsychotics. Olanzapine had the highest signal intensity in oculogyric crisis. Aripiprazole had the highest signal strength in blepharospasm. Cariprazine was associated with cataract-related ocular adverse reactions. In terms of the types of adverse events, our study found that aripiprazole was associated with 28 types of ocular adverse events, followed by quetiapine. Clozapine was only associated with two types of ocular adverse events.