■肥胖已成为世界范围内普遍存在的问题,导致各种并发症,如高脂血症,糖尿病,和心血管问题。他汀类药物作为FDA批准的抗高脂血症药物,仍然对他们的政府造成一些担忧。最近,研究人员一直在寻找天然产品作为治疗高脂血症和肥胖症的替代方法。
■这项工作旨在研究不同制剂的LepidiumSativumGardenCress(GC)的降血脂作用;口服种子,和水凝胶,与阿托伐他汀相比。
■由GC水提取物制备GC水凝胶,并对其pH进行药学评估,铺展性,种子含量,同质性,流变学,和体外释放。老鼠的体重,血糖水平,总脂谱,对肥胖大鼠进行为期一个月的肝脏生物标志物评估。此外,还进行了组织病理学研究.
■GC水凝胶具有可接受的药学特性,并在24小时内显示出持续释放性能。口服和局部GC显着降低了脂质分布,血糖和ALT,AST水平高于阴性对照组且与阿托伐他汀相当。发现口服GC比应用水凝胶对大鼠体重的百分比降低显示出显著的影响。组织病理学研究显示,与高脂饮食喂养一个月的大鼠相比,胰腺和肝脏的组织学结构具有更好的结果。
■口服GC,或局部应用的水凝胶可能是有前途的,阿托伐他汀治疗肥胖大鼠高脂血症和体重正常化的安全替代制剂。
UNASSIGNED: Obesity has become a prevalent issue worldwide, leading to various complications such as hyperlipidemia, diabetes, and cardiovascular problems. Statins as FDA approved anti-hyperlipidemic drugs, still poses some concerns upon their administration. Recently, researchers have looked for natural products as an alternative to manage hyperlipidemia and obesity.
UNASSIGNED: This work aimed to study the hypolipidemic effect of Lepidium Sativum Garden Cress (GC) from different preparations; orally administered seeds, and hydrogel, in comparison to
atorvastatin.
UNASSIGNED: GC hydrogel was prepared from the GC aqueous extract and pharmaceutically evaluated for its pH, spreadability, seeds content, homogeneity, rheology, and in vitro release. The rat\'s body weight, blood glucose levels, total lipid profile, and liver biomarkers were evaluated on obese rats for one month. In addition, the histopathology study was also performed.
UNASSIGNED: GC hydrogel had acceptable pharmaceutical properties and showed a sustained release performance over 24 h. Oral and topical GC significantly reduced the lipid profiles, blood sugar and ALT, AST levels more than the negative control group and comparable to
atorvastatin. It was found that oral GC showed a significant effect on the percentage decrease in the rat\'s body weight than the applied hydrogel. Histopathology study revealed a better outcome in the histological structure of pancreas and liver compared with rats feed on high fat diet post treatment for one month.
UNASSIGNED: GC orally administered, or topically applied hydrogel could be a promising, safe alternative formulation to
atorvastatin in managing hyperlipidemia and normalizing body weight of obese rats.