PDF(Pubmed)
Abstract：
Free radicals and reactive oxygen species initiate when the oxidative stress arises. (1) Background: The effect of natural molecules on oxidative stress in hyperlipidemic rats, taking statins, was observed. (2) Methods: One hundred and twelve white Wistar rats, males and females, were divided into seven: Group I received 20 mg of atorvastatin while groups II and III received a combination of 20 mg of atorvastatin and 100 mg of Sea buckthorn and grape extract. Groups IV and V received 100 mg of Sea buckthorn and grape extract, while groups VI and VII received only high-fat diet (HFD) and normal rodents\' fodder. After two and six months, rats were euthanized, and blood was gathered to measure the main paraclinical values and total antioxidant capacity (TAC). Also, the liver and kidney were stored for the organs\' cytoarchitecture. For statistics, two-way analysis of variance (ANOVA), was performed. (3) Results: HFD produced hyperlipidemia, accompanied by augmented serum and hepatic oxidative stress markers, in addition to a reduction in antioxidant enzyme activities and glutathione levels. Polyphenolic substances proven efficient against HFD caused oxidative stress. (4) Conclusions: Atorvastatin heightened the histological injuries caused by the fatty diet, but these were diminished by taking atorvastatin in combination with 100 mg/kg of plant extracts.
摘要：
当氧化应激发生时，自由基和活性氧会开始。(1)研究背景:天然分子对高脂血症大鼠氧化应激的影响,服用他汀类药物，被观察到。（2）方法：一百一十二只白色Wistar大鼠，男性和女性，分为七个：第一组接受20mg阿托伐他汀，而第二组和第三组接受20mg阿托伐他汀和100mg沙棘和葡萄提取物的组合。第IV组和第V组接受100毫克沙棘和葡萄提取物，而VI组和VII组仅接受高脂饮食（HFD）和正常啮齿动物饲料。两个月和六个月后，对大鼠实施安乐死,收集血液以测量主要临床值和总抗氧化能力（TAC）。此外，肝脏和肾脏被储存用于器官的细胞结构。对于统计数据，双向方差分析(ANOVA)，已执行。(3)结果:HFD产生高脂血症,伴随着增强的血清和肝脏氧化应激标志物，除了抗氧化酶活性和谷胱甘肽水平的降低。多酚物质被证明对HFD引起的氧化应激有效。(4)结论:阿托伐他汀加重了脂肪饮食引起的组织学损伤,但是通过服用阿托伐他汀与100mg/kg植物提取物的组合，这些减少了。
