未经证实:水缺乏性干眼症是一种慢性和潜在的视力威胁疾病,这是由于泪腺的功能障碍而发生的。这次审查的目的是描述理解方面的各种最新发展,房水缺乏性干眼症泪腺功能不全的诊断与治疗.
UNASSIGNED:使用PubMed进行MEDLINE数据库搜索的关键字为:“干眼症/综合征”,“房水缺乏/缺乏干眼症”,“泪腺”和“干燥综合征”。在扫描了750份相关摘要后,审查中包括2016年至2021年以英语发表的73篇合格文章。
UNASSIGNED:组织病理学和超微结构研究揭示了结膜炎引起的房水缺乏的发病机制的新见解,泪腺腺泡不受累并保留其分泌特性,同时观察到腺体的显着超微结构变化。诊断的最新进展包括直接临床评估泪腺形态和分泌的技术,泪膜渗透压,泪膜溶菌酶和乳铁蛋白水平,泪膜干涉术和泪腺共聚焦显微镜。房水缺乏干眼症的治疗进展,除了基于纳米粒子的眼泪替代品,包括促分泌素,如迪加福索四钠和瑞巴派特,抗炎外用药物,如环孢菌素和lifitegrast的纳米胶束形式,巩膜隐形眼镜,神经刺激,和针灸来增加泪液的产生量,小涎腺移植,粪便微生物移植,泪腺再生与间充质干细胞治疗.
未经批准:在理解方面取得了重大进展,泪腺功能不全的诊断和治疗及其在房水缺乏干眼症中的作用已在过去十年的后半期发生。其中,在更新的药物配方和再生医学方面的转化突破是最有希望的。
UNASSIGNED: Aqueous deficiency dry eye disease is a chronic and potentially sight-threatening condition, that occurs due to the dysfunction of the lacrimal glands. The aim of this review was to describe the various recent developments in the understanding, diagnosis and treatment of lacrimal gland insufficiency in aqueous deficiency dry eye disease.
UNASSIGNED: A MEDLINE database search using PubMed was performed using the keywords: \"dry eye disease/syndrome\", \"aqueous deficient/deficiency dry eye disease\", \"lacrimal gland\" and \"Sjogren\'s syndrome\". After scanning through 750 relevant abstracts, 73 eligible articles published in the English language from 2016 to 2021 were included in the review.
UNASSIGNED: Histopathological and ultrastructural studies have revealed new insights into the pathogenesis of cicatrising conjunctivitis-induced aqueous deficiency, where the lacrimal gland acini remain uninvolved and retain their secretory property, while significant ultrastructural changes in the gland have been observed. Recent advances in diagnosis include the techniques of direct clinical assessment of the lacrimal gland morphology and secretion, tear film osmolarity, tear film lysozyme and lactoferrin levels, tear film interferometry and lacrimal gland confocal microscopy. Developments in the treatment of aqueous deficiency dry eye disease, apart from the nanoparticle-based tear substitutes, include secretagogues like diquafosol tetrasodium and rebamipide, anti-inflammatory topical agents like nanomicellar form of cyclosporine and lifitegrast, scleral contact lenses, neurostimulation, and acupuncture for increasing the amount of tear production, minor salivary gland transplantation, faecal microbial transplantation, lacrimal gland regeneration and mesenchymal stem cell therapy.
UNASSIGNED: Significant advances in the understanding, diagnosis and management of lacrimal gland insufficiency and its role in aqueous deficiency dry eye disease have taken place within the second half of the last decade. Of which, translational breakthroughs in terms of newer drug formulations and regenerative medicine are most promising.