PDF(Pubmed)
Abstract：
Dry eye disease (DED) is a broad term that includes a diverse group of clinical disorders. Aqueous-deficient dry eye (ADDE), a subtype of DED, is characterized by decreased tear production by the lacrimal gland. It can be seen in up to one-third of individuals with DED and can be comorbid with a systemic autoimmune process or occur secondary to an environmental insult. Since ADDE can be a source of long-term suffering and severe visual impairment, early identification and adequate treatment are imperative. Multiple etiologies can underlie ADDE, and it is critical to identify the underlying cause to not only improve the ocular health but also to improve the overall quality of life and well-being of affected individuals. This review discusses the various etiologies of ADDE, highlights a pathophysiology-based approach for evaluating underlying contributors, outlines various diagnostic tests, and reviews treatment options. We present the current standards and discuss ongoing research in this field. Through this review, we propose a treatment algorithm that would be useful for an ophthalmologist in diagnosing and managing individuals with ADDE.
摘要：
干眼症（DED）是一个广泛的术语，包括一组不同的临床疾病。水缺乏性干眼（ADDE），DED的子类型，其特征在于泪腺的泪液产生减少。它可以在多达三分之一的DED患者中看到，并且可以与全身性自身免疫过程并存或继发于环境损害。由于ADDE可能是长期痛苦和严重视力障碍的来源，早期识别和适当的治疗是必要的。多种病因可以作为ADDE的基础，至关重要的是确定根本原因，不仅要改善眼部健康，还要改善受影响个体的整体生活质量和福祉。这篇综述讨论了ADDE的各种病因，强调了一种基于病理生理学的方法来评估潜在的贡献者，概述了各种诊断测试，并回顾治疗方案。我们介绍了当前的标准，并讨论了该领域正在进行的研究。通过这次审查,我们提出了一种治疗算法,该算法将有助于眼科医生诊断和管理ADDE患者.
