越来越普遍,并与医疗保健环境相关联,念珠菌感染非常重要,因为该属的某些物种可以产生抗真菌抗性。我们提供流行病学数据,抗真菌药敏,以及非白色念珠菌和非耳念珠菌的遗传多样性影响哥伦比亚一家四级医院的危重患者。九十七株导致侵袭性感染,通过常规方法鉴定超过18个月,被研究过。来自受这些酵母影响的患者的数据,包括性,年龄,合并症,治疗,和结果,进行了分析。确定了分离株的抗真菌敏感性,并对核糖体DNA进行了测序。近带念珠菌,热带念珠菌,光滑念珠菌,都柏林念珠菌,念珠菌和念珠菌引起所有侵袭性念珠菌病的48.5%。该物种主要从血液中回收(50%)。患者多为男性(53.4%),在18天到93岁之间,ICU住院(70.7%)。总死亡率为46.6%,但ICU里的病人,使用抗生素,患有糖尿病,或光滑梭菌感染更有可能死亡。抗性分离株在近融合梭菌中鉴定,C.热带,和C.glabrata.本研究为新兴念珠菌的监测提供了流行病学数据,突出它们的临床影响,以及抗真菌耐药性和克隆扩散的出现。
Increasingly common and associated with healthcare settings, Candida infections are very important, since some species of this genus can develop antifungal resistance. We contribute data on the epidemiology, antifungal susceptibility, and genetic diversity of Candida non-albicans and non-auris affecting critically ill patients in a fourth-level hospital in Colombia. Ninety-seven isolates causing invasive infections, identified by conventional methods over 18 months, were studied. Data from patients affected by these yeasts, including sex, age, comorbidities, treatment, and outcome, were analysed. The antifungal susceptibility of the isolates was determined, and the ribosomal DNA was sequenced. Candida parapsilosis, Candida tropicalis, Candida glabrata, Candida dubliniensis, and Candida guilliermondii caused 48.5% of all cases of invasive candidiasis. The species were mainly recovered from blood (50%). Patients were mostly men (53.4%), between 18 days and 93 years old, hospitalized in the ICU (70.7%). Overall mortality was 46.6%, but patients in the ICU, using antibiotics, with diabetes mellitus, or with C. glabrata infections were more likely to die. Resistant isolates were identified in C. parapsilosis, C. tropicalis, and C. glabrata. This study provides epidemiological data for the surveillance of emerging Candida species, highlighting their clinical impact, as well as the emergence of antifungal resistance and clonal dispersal.