PDF(Pubmed)
Abstract：
UNASSIGNED: Over recent decades, the number of outbreaks caused by fungi has increased for humans, plants (including important crop species) and animals. Yet this problem is compounded by emerging antifungal drug resistance in pathogenic species. Resistance develops over time when fungi are exposed to drugs either in the patient or in the environment.
UNASSIGNED: Novel resistant variants of fungal pathogens that were previously susceptible are evolving (such as Aspergillus fumigatus) as well as newly emerging fungal species that are displaying antifungal resistance profiles (e.g. Candida auris and Trichophyton indotineae).
UNASSIGNED: This review highlights the important topic of emerging antifungal resistance in fungal pathogens and how it evolved, as well as how this relates to a growing public health burden.
UNASSIGNED: Novel resistant variants of fungal pathogens that were previously susceptible are evolving (such as Aspergillus fumigatus) as well as newly emerging fungal species that are displaying antifungal resistance profiles (e.g. Candida auris and Trichophyton indotineae).
UNASSIGNED: This review highlights the important topic of emerging antifungal resistance in fungal pathogens and how it evolved, as well as how this relates to a growing public health burden.
摘要：
■近几十年来，真菌引起的人类爆发的数量有所增加，植物（包括重要的作物品种）和动物。然而，致病物种中出现的抗真菌药物耐药性加剧了这一问题。当真菌暴露于患者或环境中的药物时，耐药性会随着时间的推移而发展。
先前易感的真菌病原体的新抗性变体正在进化（例如烟曲霉）以及显示抗真菌抗性谱的新出现的真菌物种（例如耳念珠菌和吲哚毛癣菌）。
■这篇综述强调了真菌病原体中出现的抗真菌耐药性及其进化的重要主题，以及这与日益增长的公共卫生负担的关系。
先前易感的真菌病原体的新抗性变体正在进化（例如烟曲霉）以及显示抗真菌抗性谱的新出现的真菌物种（例如耳念珠菌和吲哚毛癣菌）。
■这篇综述强调了真菌病原体中出现的抗真菌耐药性及其进化的重要主题，以及这与日益增长的公共卫生负担的关系。
