■盐酸戊乙奎醚(PHC)已被用作抗胆碱能药物,用于治疗急性有机磷农药中毒(AOPP)。这项荟萃分析的目的是探讨PHC在AOPP中使用抗胆碱能药物方面是否优于阿托品。
■我们搜索了Scopus,Embase,科克伦,PubMed,ProQuest,奥维德,WebofScience,中国科技期刊数据库(VIP),独秀,中国生物医学文献(CBM),万方,和中国国家知识基础设施(CNKI),从成立到2022年3月。在纳入所有合格的随机对照试验(RCTs)后,我们进行了质量评估,数据提取,和统计分析。使用风险比率(RR)进行统计,加权平均差(WMD),和标准平均差(SMD)。
■我们的荟萃分析包括来自中国242家不同医院的240项研究的20797名受试者。与阿托品组相比,PHC组死亡率下降(RR=0.20,95%置信区间[CI]:0.16-0.25,P<0.001),住院时间(WMD=-3.89,95%CI:-4.37至-3.41,P<0.001),并发症总发生率(RR=0.35,95%CI:0.28-0.43,P<0.001),不良反应总发生率(RR=0.19,95%CI:0.17-0.22,P<0.001),总症状消失时间(SMD=-2.13,95%CI:-2.35至-1.90,P<0.001),胆碱酯酶活性恢复到正常值50-60%的时间(SMD=-1.87,95%CI:-2.03至-1.70,P<0.001),昏迷时间(WMD=-5.57,95%CI:-7.20至-3.95,P<0.001),机械通气时间(WMD=-2.16,95%CI:-2.79~-1.53,P<0.001)。
■作为AOPP中的抗胆碱能药物,PHC与阿托品相比具有若干优势。
UNASSIGNED: Penehyclidine hydrochloride (PHC) has been used for many years as an anticholinergic drug for the treatment of acute organophosphorus pesticide poisoning (AOPP). The purpose of this meta-analysis was to explore whether PHC has advantages over atropine in the use of anticholinergic drugs in AOPP.
UNASSIGNED: We searched Scopus, Embase, Cochrane, PubMed, ProQuest, Ovid, Web of Science, China Science and Technology Journal Database (VIP), Duxiu, Chinese Biomedical literature (CBM), WanFang, and Chinese National Knowledge Infrastructure (CNKI), from inception to March 2022. After all qualified randomized controlled trials (RCTs) were included, we conducted quality evaluation, data extraction, and statistical analysis. Statistics using risk ratios (RR), weighted mean difference (WMD), and standard mean difference (SMD).
UNASSIGNED: Our meta-analysis included 20,797 subjects from 240 studies across 242 different hospitals in China. Compared with the atropine group, the PHC group showed decreased mortality rate (RR=0.20, 95% confidence intervals [CI]: 0.16-0.25, P <0.001), hospitalization time (WMD=-3.89, 95% CI: -4.37 to -3.41, P <0.001), overall incidence rate of complications (RR=0.35, 95% CI: 0.28-0.43, P <0.001), overall incidence of adverse reactions (RR=0.19, 95% CI: 0.17-0.22, P <0.001), total symptom disappearance time (SMD=-2.13, 95% CI: -2.35 to -1.90, P <0.001), time for cholinesterase activity to return to normal value 50-60% (SMD=-1.87, 95% CI: -2.03 to -1.70, P <0.001), coma time (WMD=-5.57, 95% CI: -7.20 to -3.95, P <0.001), and mechanical ventilation time (WMD=-2.16, 95% CI: -2.79 to -1.53, P <0.001).
UNASSIGNED: PHC has several advantages over atropine as an anticholinergic drug in AOPP.