环境空气污染暴露和低度炎症与肺功能的关系仍然不确定。在这项研究中,在英国生物银行登记了276,289名受试者。个人暴露于环境空气污染(包括二氧化氮[NO2],氮氧化物[NOx]),和颗粒物[PM2.5,PM10,PMarrow])通过使用土地利用回归模型进行了估算。测试用力肺活量(FVC)和1s用力呼气量(FEV1),并计算每位受试者的低度炎症评分(INFLA评分)。在这项横断面研究中,空气污染的中值浓度为PM2.5的9.89µg/m3,PM10的15.98µg/m3,PM2.5的6.09µg/m3,NO2为25.60µg/m3,NOx为41.46µg/m3,分别。我们观察到PM2.5,PM10,PM2.5,NO2、NOx与肺功能呈负相关。此外,观察到PM暴露与低度炎症之间存在显著正相关.PM2.5、PM10和PMrosh的每四分位数间距(IQR)增加与较高的INFLA评分相关,β(95%CI)为0.06(0.03,0.08),0.03(0.02,0.05),和0.03(0.01,0.04),分别。此外,我们发现INFLA评分与肺功能之间存在显著负相关.INFLA评分增加1个单位与FVC和FEV1分别减少12.41-和11.31-ml相关。与低空气污染暴露和低INFLA评分的个体相比,高空气污染和高INFLA评分的参与者的FVC和FEV1最低.此外,我们观察到INFLA评分可以改变PM2.5、NO2和NOx与FVC和FEV1的关系(P交互作用<0.05)。与INFLA得分较低的受试者相比,INFLA得分较高的受试者中空气污染物对肺功能的负面影响更为明显。总之,我们证明了环境空气污染与肺功能之间的负相关,观察到的关联通过低度炎症得到加强和修饰。
The associations of ambient air pollution exposure and low-grade inflammation with lung function remain uncertain. In this study, 276,289 subjects were enrolled in the UK Biobank. Individual exposure to ambient air pollution (including nitrogen dioxide [NO2], nitrogen oxides [NOx]), and particulate matter [PM2.5, PM10, PMcoarse]) were estimated by using the land-use regression model. Forced vital capacity (FVC) and forced expiratory volume in 1 s (FEV1) were tested, and low-grade inflammation score (INFLA score) was calculated for each subject. In this cross-sectional study, the median concentrations of air pollution were 9.89 µg/m3 for PM2.5, 15.98 µg/m3 for PM10, 6.09 µg/m3 for PMcoarse, 25.60 µg/m3 for NO2, and 41.46 µg/m3 for NOx, respectively. We observed that PM2.5, PM10, PMcoarse, NO2, NOx was negatively associated with lung function. Besides, significant positive associations between PM exposure and low-grade inflammation were noted. Per interquartile range (IQR) increase in PM2.5, PM10, and PMcoarse was related to higher INFLA score, and the β (95 % CI) was 0.06 (0.03, 0.08), 0.03 (0.02, 0.05), and 0.03 (0.01, 0.04), respectively. Additionally, we found significant negative associations between INFLA scores and lung function. One-unit increase in INFLA score was linked with 12.41- and 11.31-ml decreases in FVC and FEV1, respectively. Compared with individuals with low air pollution exposure and low INFLA scores, participants with high air pollution and high INFLA scores had the lowest FVC and FEV1. Additionally, we observed that INFLA scores could modify the relationships of PM2.5, NO2, and NOx with FVC and FEV1 (Pinteraction <0.05). The negative impact of air pollutants on lung function was more pronounced in subjects with high INFLA scores in comparison to those with low INFLA scores. In conclusion, we demonstrated negative associations between ambient air pollution and lung function, and the observed associations were strengthened and modified by low-grade inflammation.