■Alpha-Gal综合征(AGS),一种独特形式的哺乳动物肉类过敏,具有独特的特征,使其与典型的IgE介导的食物超敏反应区分开来。AGS通常在摄入哺乳动物肉类后3-6小时诱导过敏反应,比如牛肉,猪肉,或者羊肉。这种延长的反应时间将AGS与其他食物过敏区分开来,这通常会引起更直接的反应。
■作者介绍了一例35岁的男性患者,他不知道,几年来一直出现与Alpha-Gal过敏一致的症状。他的症状只有在他的饮食中完全消除哺乳动物肉之后才会消退。直到那时,人们才考虑了AGS的可能性。完全禁欲从哺乳动物的肉,肉类副产品,和其他含α-Gal的食物是AGS最有效的预防策略。到目前为止,尚未确定AGS的最终治疗方法。超敏反应的治疗方案取决于反应的严重程度,从抗组胺药物到肾上腺素的治疗。
■AGS患者在乳制品消费方面存在相当大的差异。一些患有AGS的人可以安全地食用乳制品,没有任何不良反应,而其他人则建议由于潜在的过敏反应而弃权。AGS患者乳制品耐受性的这种差异值得进一步研究。
UNASSIGNED: Alpha-Gal syndrome (AGS), a distinct form of mammalian meat allergy, presents unique characteristics that set it apart from typical IgE-mediated food hypersensitivities. AGS induces an allergic response typically 3-6 h post-ingestion of mammalian meat, such as beef, pork, or lamb. This prolonged reaction time differentiates AGS from other food allergies, which usually provoke a more immediate response.
UNASSIGNED: The authors present a case of a 35-year-old male patient who, unbeknownst to him, had been experiencing symptoms consistent with Alpha-Gal allergy for several years. His symptoms only subsided upon the complete elimination of mammalian meat from his diet. It was only then that the possibility of AGS was considered. Complete abstinence from mammalian meat, meat by-products, and other α-Gal containing foods is the most effective preventative strategy for AGS. No definitive cure for AGS has been established as of now. Treatment protocols for hypersensitivity reactions are contingent upon the severity of the reaction, with therapies ranging from antihistamine medications to the administration of epinephrine.
UNASSIGNED: There is considerable variability among AGS patients concerning the consumption of dairy products. Some individuals with AGS can safely consume dairy products without any adverse reactions, while others are advised to abstain due to potential allergenic responses. This variability in dairy tolerance among AGS patients warrants further investigation.