目的:使用发光二极管(LED)进行光生物调节似乎是长期COVID的有希望的选择。这项回顾性研究评估了LED照射在长期COVID过程中治疗TE的有效性,包括有和没有雄激素性脱发的患者。
方法:对COVID后脱发患者进行回顾性单中心图表回顾。根据脱发的类型和治疗方法,将140例纳入研究的患者分为四组:1)LED治疗(TELED),2)未使用LED疗法(TELED-),3)用LED治疗(TE+AGALED+),和4)未使用LED治疗(TE+AGALED-)的静止期脱发和雄激素性脱发。比较临床和三镜参数。
结果:12周后,与未接受LED治疗的患者相比,在TELED+和TE+AGALED+中,脱发停止和毛发拉拔试验阴性更为常见(分别为p<0.001,p=0.035).在接受LED照射治疗的患者中,毛囊单位内的粗毛数量增加和毛发数量增加更为常见,不管脱发的类型,与没有LED治疗的患者相比。
结论:研究表明LED治疗是安全的,耐受性良好,似乎是长期COVID患者对TE的一种有希望的治疗选择。它可以用作辅助治疗,导致更快的脱发减少,增强头发再生以及毛干厚度和密度。
OBJECTIVE: Photobiomodulation with the use of light-emitting diodes (LEDs) seems to be a promising option for long COVID. This retrospective study evaluates the efficiency of LED irradiation in the treatment of TE in the course of long COVID in patients with and without androgenetic
alopecia.
METHODS: A retrospective single-centre chart review of patients with post-COVID hair loss was performed. 140 patients enrolled to the study were divided into four groups depending on the type of
alopecia and treatment: 1) telogen effluvium with LED therapy (TE LED+), 2) telogen effluvium without LED therapy (TE LED-), 3) telogen effluvium and androgenetic
alopecia with LED therapy (TE+AGA LED+), and 4) telogen effluvium and androgenetic
alopecia without LED therapy (TE+AGA LED-). Clinical and trichoscopic parameters were compared.
RESULTS: After 12 weeks, cessation of hair loss and a negative hair pull test were more common in TE LED+ and TE+AGA LED+ in comparison to the patients without LED therapy (p<0.001, p=0.035, respectively). An increased number of thick hairs and an increased number of hairs within follicular units were more common in patients treated with LED irradiation, regardless of the type of
alopecia, compared to the patients without LED therapy.
CONCLUSIONS: The study revealed that LED therapy is safe, well tolerated and seems to be a promising therapeutic option for TE in patients with long COVID. It can be used as adjuvant therapy leading to faster reduction of hair loss, enhancing hair regrowth as well as hair shaft thickness and density.