杏仁船体,占杏仁鲜重一半以上的大量副产品,由于其丰富的纤维和生物活性含量,最近引起了人们的关注。尽管有这种巨大的兴趣,关于其毒性的数据仍然很少。根据经济合作与发展组织(经合组织)第423条准则,这项研究使用从三个主要杏仁品种Butte加工的杏仁壳粉进行了急性口服毒性试验,蒙特利,和Nonpareil对BALB/c雌性小鼠,施用剂量为300mg/kg体重(bw),2000毫克/千克体重,和5000毫克/千克体重,经过14天的观察。结果表明,杏仁壳粉无毒,与全球统一制度的分类保持一致。施用高达5000mg/kgbw的所有三个品种的杏仁壳粉(雌性BALB/c小鼠)和10,000mg/kgbw的蒙特利杏仁壳粉(雌性和雄性小鼠)在死亡率方面没有任何不利影响,体重变化,食物摄入量,器官重量比,和临床生物化学。此外,组织病理学检查未发现器官异常。这项研究证明了在实验条件下杏仁壳作为可食用食品成分的无毒性质,鼓励进一步探索其安全消费潜力及其健康益处。
Almond hull, a substantial byproduct constituting more than half of almond fresh weight, has garnered recent attention due to its abundance in fiber and bioactive content. Despite this huge interest, data on its toxicity remain scarce. In line with the Organization for Economic Cooperation and Development (OECD) 423 guidelines, this study conducted an acute oral toxicity test using almond hull powders processed from three major almond varieties of Butte, Monterey, and Nonpareil on BALB/c female mice, administering dosages of 300 mg/kg body weight (bw), 2000 mg/kg bw, and 5000 mg/kg bw, with observations over a 14-day period. The results indicated that almond hull powders were non-toxic, aligning with the Globally Harmonized System\'s classification. Administering up to 5000 mg/kg bw of all three varieties of almond hull powders (female BALB/c mice) and 10,000 mg/kg bw of Monterey almond hull powders (both female and male mice) induced no adverse effects in terms of mortality, body weight changes, food intake, organ to weight ratio, and clinical biochemistry. Additionally, histopathological examination revealed no organ abnormalities. This study demonstrates the non-toxic nature of almond hull as an edible food ingredient under experimental conditions, encouraging the further exploration of its potential for safe consumption and its health benefits.