背景:甲状腺的Hurthle细胞瘤是一组罕见且神秘的肿瘤,其特征在于Hurthle细胞的存在表现出丰富的嗜酸性细胞质和许多线粒体。尽管发病率低,它们带来了诊断挑战,并显示出不同的临床结果.这项研究旨在对印度南部三级护理中心内Hurthle细胞肿瘤的临床病理特征进行全面分析。
方法:通过回顾性方法,我们分析了在三级护理中心诊断和治疗5年的Hurthle细胞肿瘤病例.临床,放射学,和组织病理学数据被精心收集和仔细检查。这项研究的重点是研究人口统计细节,出现症状,成像特征,细胞学发现,手术管理,和患者的术后结局。
结果:在研究期间共发现32例Hurthle细胞肿瘤。大多数患者是女性(84%)。Hurthle细胞癌的平均年龄为49.6岁。甲状腺肿大和颈部肿块是最常见的主诉。细针吸取细胞学检查显示33%的病例中提示Hurthle细胞肿瘤的特征性特征。甲状腺全切除术仍然是主要的手术方法。组织病理学评估证实62.5%的病例为良性腺瘤,37.5%的病例为恶性肿瘤。在恶性肿瘤中,67%表现为包膜侵犯,33%表现为血管侵犯。在患者中,33.3%接受辅助放疗。总生存率为100%。在我们的研究中,我们发现大于3cm的甲状腺结节显示出较高的Hurthle细胞癌倾向.
结论:我们的研究结果支持管理Hurthle细胞肿瘤的多学科方法,专注于根据个体特征为每位患者量身定制的治疗计划。通过承认女性占主导地位,评估结节大小,采用甲状腺切除术和消融治疗的组合,临床医生可以优化患者的护理,并为受Hurthle细胞肿瘤影响的患者提供更好的长期预后和生活质量。持续的研究和协作努力对于提高我们的理解和完善治疗策略是必要的。为将来改善预后和加强患者管理铺平道路。
BACKGROUND: Hurthle cell tumors of the thyroid gland constitute a rare and enigmatic group of neoplasms, characterized by the presence of Hurthle cells exhibiting abundant eosinophilic cytoplasm and numerous mitochondria. Despite their low incidence, they pose diagnostic challenges and display diverse clinical outcomes. This study aims to provide a comprehensive analysis of the clinicopathological profile of Hurthle cell tumors within a tertiary care center in South India.
METHODS: Through a retrospective approach, we analyzed cases of Hurthle cell tumors diagnosed and treated at a tertiary care center over a five-year period. Clinical, radiological, and histopathological data were meticulously collected and scrutinized. The study focused on examining demographic details, presenting symptoms, imaging features, cytological findings, surgical management, and postoperative outcomes of the patients.
RESULTS: A total of 32 cases of Hurthle cell tumors were identified during the study period. The majority of patients were female (84%), with a mean age of 49.6 years for Hurthle cell carcinoma. Thyroid enlargement and neck mass were the most common presenting complaints. Fine-needle aspiration cytology showed characteristic features suggestive of Hurthle cell tumors in 33% of cases. Total thyroidectomy remains the mainstay surgical approach. Histopathological evaluation confirmed 62.5% of cases as benign adenomas and 37.5% as malignant carcinomas. Among malignant cases, 67% showed capsular invasion and 33% demonstrated vascular invasion. Of the patients, 33.3% received adjuvant radiotherapy. The overall survival rate was 100%. In our study, we found that thyroid nodules larger than 3 cm demonstrated a higher propensity for Hurthle cell carcinoma.
CONCLUSIONS: Our findings support the multidisciplinary approach in managing Hurthle cell tumors, with a focus on tailored treatment plans for each patient based on individual characteristics. By recognizing the female predominance, assessing nodule size, and employing a combination of thyroidectomy and ablative therapy, clinicians can optimize patient care and contribute to better long-term prognosis and quality of life for those affected by Hurthle cell tumors. Continued research and collaborative efforts are necessary to advance our understanding and refine treatment strategies, paving the way for improved outcomes and enhanced patient management in the future.