该研究旨在研究脂肪细胞因子与心血管事件风险的关系,并确定年轻人群中脂肪细胞对心血管事件预后的阈值。
方法:本研究为流行病学队列研究。该分析包括1240名25-44岁的人。将终点合并,包括:心血管疾病死亡,心肌梗塞,可能的心肌梗塞,急性脑血管意外,心血管疾病住院治疗,和血运重建。用MILLIPLEX组测定脂肪细胞因子。
结果:在被检查的人群中,1.7%的心血管事件病例在队列观察中被检测到,其中28.6%为致命事件。在男人中,心血管终点的记录频率是女性的4.3倍(17(81%)vs.4(19%),p=0.003)。在有心血管事件的个体中,动脉高血压(2.6倍),糖尿病(8.6倍),与没有心血管事件的个体相比,超重/肥胖(1.5倍)的发生率更高.对于肿瘤坏死因子-α(TNFa),阈值为2.5pg/mL,敏感性评价(Se)为85.7%,特异性(Sp)为83.3%。对于胰淀素,阈值为10.5pg/mL,硒为73.7%,Sp为67.0%。对于胰腺多肽(PP),阈值为43.7pg/mL,硒为85.7%,Sp为56.7%。
结论:评估年轻人心血管事件风险的方法包括确定胰淀素的水平,PP,和血清中的TNFα。预测心血管事件的临界点是胰淀素水平高于10.5pg/mL,PP高于43.7pg/mL,或TNFa降低到3.8pg/mL以下。
The research was aimed to study the associations of
adipocytokines with the risk of cardiovascular events and to determine the threshold values of adipocytes for the prognosis of cardiovascular events in a young population.
METHODS: The study is an epidemiological cohort study. The analysis included 1240 people aged 25-44 years. The endpoint was combined and included: death from cardiovascular disease, myocardial infarction, probable myocardial infarction, acute cerebrovascular accident, hospitalization for cardiovascular disease, and revascularization.
Adipocytokines were determined with a MILLIPLEX panel.
RESULTS: In the examined population, 1.7% of cases of cardiovascular events were detected during cohort observation, of which 28.6% were fatal events. In men, cardiovascular endpoints were recorded 4.3 times more often than in women (17 (81%) vs. 4 (19%), p = 0.003). In individuals with cardiovascular events, arterial hypertension (2.6 times), diabetes mellitus (8.6 times), and overweight/obesity (1.5 times) were more often recorded compared to individuals without cardiovascular events. For tumor necrosis factor-alpha (TNFa), the threshold value was 2.5 pg/mL, with sensitivity assessment (Se) at 85.7% and specificity (Sp) at 83.3%. For amylin, the threshold value was 10.5 pg/mL, with Se at 73.7% and Sp at 67.0%. For pancreatic polypeptide (PP), the threshold value was 43.7 pg/mL, with Se at 85.7% and Sp at 56.7%.
CONCLUSIONS: A method for assessing the risk of cardiovascular events in young people includes determining the levels of amylin, PP, and TNFa in blood serum. The cut-off points for predicting cardiovascular events were levels of amylin above 10.5 pg/mL, PP above 43.7 pg/mL, or a decrease in TNFa below 3.8 pg/mL.