PDF(Pubmed)
Abstract：
Adiposity, a state characterized by excessive accumulation of body fat, is closely linked to metabolic complications and the secretion of specific adipokines. This study explores the potential of exercise and Spirulina supplementation to mitigate these complications and modulate adipokine release associated with obesity. The primary objective of this investigation was to examine the impact of a 12-week regimen of high-intensity training combined with Spirulina supplementation on adipokine concentrations and lipid profiles in male individuals with obesity (N = 44). The participants were randomly distributed into four groups, each consisting of 11 participants: a control group (CG), a supplement group (SG), a training group (TG), and a training plus supplement group (TSG). The intervention comprised a 12-week treatment involving Spirulina supplementation (6 g capsule daily), a 12-week high-intensity interval training (HIIT) protocol with three sessions per week, or a combined approach. Following the interventions, metabolic parameters, anthropometric measurements, cardiorespiratory indices, and circulating adipokines [CRP, Sema3C, TNF-α, IL-6, MCP1, IL-8] were assessed within 48 h of the before and final training session. Statistical analyses revealed significant differences across all measures among the groups (p < 0.05). Notably, post hoc analyses indicated substantial disparities between the CG and the three interventional groups regarding body weight (p < 0.05). The combined training and supplementation approach led to noteworthy reductions in low-density lipoprotein (LDL), total cholesterol (TC), and triglyceride (TGL) levels (all p < 0.0001), coupled with an elevation in high-density lipoprotein-cholesterol (HDL-C) levels (p = 0.0001). Furthermore, adipokine levels significantly declined in the three intervention groups relative to the CG (p < 0.05). The findings from this 12-week study demonstrate that Spirulina supplementation in conjunction with high-intensity interval training reduced adipokine levels, improved body weight and BMI, and enhanced lipid profiles. This investigation underscores the potential of Spirulina supplementation and high-intensity interval training as a synergistic strategy to ameliorate obesity-related complications and enhance overall cardiometabolic well-being in obese males.
摘要：
肥胖，一种以体内脂肪过度积累为特征的状态，与代谢并发症和特定脂肪因子的分泌密切相关。这项研究探讨了运动和补充螺旋藻减轻这些并发症并调节与肥胖相关的脂肪因子释放的潜力。这项研究的主要目的是研究12周高强度训练联合螺旋藻补充方案对肥胖男性个体（N=44）脂肪因子浓度和脂质分布的影响。参与者随机分为四组，每个由11名参与者组成：一个对照组(CG)，补充组(SG)，训练组（TG），和一个培训加补充小组(TSG)。干预措施包括12周治疗，包括补充螺旋藻（每天6克胶囊），为期12周的高强度间歇训练（HIIT）协议，每周三次，或组合的方法。在干预之后，代谢参数，人体测量,心肺指数,和循环脂肪因子[CRP，Sema3C,TNF-α,在训练前和最后一次训练的48小时内评估IL-6，MCP1，IL-8]。统计分析显示各组间所有测量值的显著差异(p<0.05)。值得注意的是,事后分析显示,CG组和3个干预组之间在体重方面存在显著差异(p<0.05).训练和补充相结合的方法导致低密度脂蛋白（LDL）显着降低，总胆固醇(TC),和甘油三酯（TGL）水平（所有p<0.0001），再加上高密度脂蛋白胆固醇（HDL-C）水平升高（p=0.0001）。此外，相对于CG，三个干预组的脂肪因子水平显着下降（p<0.05）。这项为期12周的研究结果表明，补充螺旋藻与高强度间歇训练相结合可以降低脂肪因子水平，改善体重和BMI，和增强的脂质分布。这项研究强调了补充螺旋藻和高强度间歇训练作为改善肥胖男性肥胖相关并发症和提高整体心脏代谢健康的协同策略的潜力。
