■现有证据表明,ABO血型与2019年冠状病毒病(COVID-19)的严重结局之间存在联系。我们的目的是评估整个大流行期间各变异株的血型与严重结局之间的关系。
■这是来自密歇根州东南部大型卫生系统的多中心回顾性观察队列分析,使用电子病历评估紧急情况。住院治疗,和基于ABO血型的COVID-19的严重结局。对2020年3月1日至2022年12月31日连续到急诊科就诊并初步诊断为COVID-19(U07.1)的成年患者进行了评估。在三个不同的时间间隔内出现的患者,Delta,和Omicron变体优势包括在分析中。排除包括没有ABO血型记录,前28天内PCRCOVID-19检测阳性,如果从卫生系统转移出去。严重结局包括重症监护病房入院,机械通气,或死亡,which,作为复合材料,代表了我们的主要结果。次要结果是入院和住院时间。采用logistic回归模型来检验ABO血型与严重结局之间的关系,调整年龄,性别,种族,疫苗接种状况,Elixhauser合并症指数,以及相遇发生的主要变异时间段。
■在33,796次COVID-19遭遇中,9416符合纳入标准;4071(43.2%)为O型,3417(36.3%)为A型,459(4.9%)为AB型,B型血1469(15.6%)。请注意,66.4%的队列是女性(p=0.18)。四种血型中复合重症疾病的比例相似,介于8.6%和8.9%之间(p=0.98)。请注意,53.0%的A型血液患者需要住院,与51.9%相比,50.4%,AB型的48.1%,B,血啊,分别(p<0.001)。与O型血患者(43.2%)相比,非O型血(58.8%;A的复合,AB,和B)在复合重症疾病的比例上没有统计学上的显着差异(8.8%与8.7%;p=0.81)在T1,T2和T3期间,四种血型或O型与非O型血型之间的严重结局没有显着差异。
■ABO血型与整个三角洲的COVID-19严重结局无关,阿尔法,和Omicron主导的COVID波在密歇根州东南部的一个大型卫生系统中传播。需要进一步的研究来更好地了解ABO血型是否是不断发展的COVID-19变种和其他病毒性上呼吸道感染中严重疾病的危险因素。
UNASSIGNED: Existing evidence suggests a link between ABO blood type and severe outcomes in coronavirus disease 2019 (COVID-19). We aimed to assess the relationship between blood type and severe outcomes across variant strains throughout the pandemic.
UNASSIGNED: This was a multicenter retrospective observational cohort analysis from a large health system in southeastern Michigan using electronic medical records to evaluate emergency encounters, hospitalization, and severe outcomes in COVID-19 based on ABO blood type. Consecutive adult patients presenting to the emergency department with a primary diagnosis of COVID-19 (U07.1) from March 1, 2020 through December 31, 2022 were assessed. Patients who presented during three distinct time intervals that coincided with Alpha, Delta, and Omicron variant predominance were included in the analysis. Exclusions included no record of ABO blood type, positive PCR COVID-19 test within the preceding 28 days, and if transferred from out of the health system. Severe outcomes were inclusive of intensive care unit admission, mechanical ventilation, or death, which, as a composite, represented our primary outcome. Secondary outcomes were hospital admission and length of stay. A logistic regression model was employed to test the association between ABO blood type and severe outcome, adjusting for age, sex, race, vaccination status, Elixhauser comorbidity indices, and the dominant variant time period in which the encounter occurred.
UNASSIGNED: Of the 33,796 COVID-19 encounters, 9416 met inclusion criteria; 4071 (43.2%) were type O, 3417 (36.3%) were type A, 459 (4.9%) were type AB, and 1469 (15.6%) were type B blood. Note that 66.4% of the cohort was female (p = 0.18). The proportion of composite severe disease among the four blood types was similar and ranged between 8.6% and 8.9% (p = 0.98). Note that 53.0% of type A blood patients required hospital admission, compared to 51.9%, 50.4%, and 48.1% of type AB, B, and O blood, respectively (p < 0.001). Compared to patients with O blood type (43.2%), non-O blood type (58.8%; composite of A, AB, and B) exhibited no statistically significant difference in the proportion of composite severe disease (8.8% vs. 8.7%; p = 0.81) Multivariable regression analyses exhibited no significant difference regarding the presence of severe outcomes among the four blood types or O versus non-O blood types during T1, T2, and T3.
UNASSIGNED: ABO blood type was not associated with COVID-19 severe outcomes across the Delta, Alpha, and Omicron dominant COVID waves across a large health system in southeastern Michigan. Further research is needed to better understand if ABO blood type is a risk factor for severe disease among evolving COVID-19 variants and other viral upper respiratory infections.