PDF(Pubmed)
Abstract：
UNASSIGNED: Adhesion molecules, sICAM-1 and sE-selectin appear to have a major role in the pathogenesis of coronary artery disease (CAD). The focus of this study was to investigate the relationship of sICAM-1 and sE-selectin with ABO blood groups in Pakistani patients hospitalized with acute myocardial infarction (AMI).
UNASSIGNED: In a case-control study, 116 patients of acute myocardial infarction (AMI) and 116 healthy controls (age range for both: 30 years to 70 years; both males and females) were randomly selected from the Aga Khan University and National Institute of Cardiovascular Diseases, Karachi with informed consent. The blood samples were obtained and analyzed for ABO blood groups and serum levels of sICAM-1 and sE-selectin using kit methods. Statistical tests including independent sample t-test and Two-way ANOVA were used to study the association of these adhesion molecules with blood groups in AMI patients and healthy controls. Duration of the study was from July 2021 to June 30, 2023.
UNASSIGNED: Mean serum levels of sICAM-1 were significantly higher in AMI patients compared to healthy controls (342±159 mg/dl vs. 227±104 mg/dl; p-value<0.001). Similarly, serum levels of sE-selectin were also significantly higher in AMI patients compared to healthy controls (53.6±26.9 mg/dl vs. 40.7± mg/dl; p-value<0.001). Moreover, mean concentrations of sICAM-1 and sE-selectin for the interaction between subject type (cases and control) and blood groups were statistically significant (p-value = 0.007 and p-value = 0.035, respectively).
UNASSIGNED: There is an association of adhesion molecules, sICAM-1 and sE-selectin with ABO blood groups in Pakistani patients hospitalized with AMI.
UNASSIGNED: In a case-control study, 116 patients of acute myocardial infarction (AMI) and 116 healthy controls (age range for both: 30 years to 70 years; both males and females) were randomly selected from the Aga Khan University and National Institute of Cardiovascular Diseases, Karachi with informed consent. The blood samples were obtained and analyzed for ABO blood groups and serum levels of sICAM-1 and sE-selectin using kit methods. Statistical tests including independent sample t-test and Two-way ANOVA were used to study the association of these adhesion molecules with blood groups in AMI patients and healthy controls. Duration of the study was from July 2021 to June 30, 2023.
UNASSIGNED: Mean serum levels of sICAM-1 were significantly higher in AMI patients compared to healthy controls (342±159 mg/dl vs. 227±104 mg/dl; p-value<0.001). Similarly, serum levels of sE-selectin were also significantly higher in AMI patients compared to healthy controls (53.6±26.9 mg/dl vs. 40.7± mg/dl; p-value<0.001). Moreover, mean concentrations of sICAM-1 and sE-selectin for the interaction between subject type (cases and control) and blood groups were statistically significant (p-value = 0.007 and p-value = 0.035, respectively).
UNASSIGNED: There is an association of adhesion molecules, sICAM-1 and sE-selectin with ABO blood groups in Pakistani patients hospitalized with AMI.
摘要：
■粘附分子，sICAM-1和sE-选择素似乎在冠状动脉疾病（CAD）的发病机制中起主要作用。本研究的重点是研究巴基斯坦急性心肌梗死（AMI）住院患者中sICAM-1和sE-选择素与ABO血型的关系。
■在一项病例对照研究中，从阿加汗大学和美国国家心血管疾病研究所随机选择116例急性心肌梗死（AMI）患者和116例健康对照（年龄范围：30至70岁；男性和女性），卡拉奇知情同意。获得血液样品并使用试剂盒方法分析ABO血型和sICAM-1和sE-选择素的血清水平。使用包括独立样本t检验和双向ANOVA的统计检验来研究这些粘附分子与AMI患者和健康对照中的血型的关联。研究时间为2021年7月至2023年6月30日。
■与健康对照组相比，AMI患者sICAM-1的平均血清水平明显更高（342±159mg/dlvs.227±104mg/dl；p值<0.001）。同样，与健康对照组相比，AMI患者的sE-选择素血清水平也显着较高（53.6±26.9mg/dlvs.40.7±mg/dl；p值<0.001)。此外，对于受试者类型(病例和对照组)和血型之间的相互作用,sICAM-1和sE-选择素的平均浓度具有统计学显著性(分别为p值=0.007和p值=0.035).
■存在粘附分子的缔合，巴基斯坦AMI住院患者中sICAM-1和sE-选择素与ABO血型的关系。
■在一项病例对照研究中，从阿加汗大学和美国国家心血管疾病研究所随机选择116例急性心肌梗死（AMI）患者和116例健康对照（年龄范围：30至70岁；男性和女性），卡拉奇知情同意。获得血液样品并使用试剂盒方法分析ABO血型和sICAM-1和sE-选择素的血清水平。使用包括独立样本t检验和双向ANOVA的统计检验来研究这些粘附分子与AMI患者和健康对照中的血型的关联。研究时间为2021年7月至2023年6月30日。
■与健康对照组相比，AMI患者sICAM-1的平均血清水平明显更高（342±159mg/dlvs.227±104mg/dl；p值<0.001）。同样，与健康对照组相比，AMI患者的sE-选择素血清水平也显着较高（53.6±26.9mg/dlvs.40.7±mg/dl；p值<0.001)。此外，对于受试者类型(病例和对照组)和血型之间的相互作用,sICAM-1和sE-选择素的平均浓度具有统计学显著性(分别为p值=0.007和p值=0.035).
■存在粘附分子的缔合，巴基斯坦AMI住院患者中sICAM-1和sE-选择素与ABO血型的关系。
