这篇综述强调了酶素的关键作用,一种必需的细胞粘着斑蛋白,在细胞生物学和各种疾病中。Zyxin可以协调细胞骨架的重组和动态改变,参与细胞增殖,附着力,运动性,和基因转录。在肿瘤发生和心血管疾病中,酶素异常表达与肿瘤细胞活性和心脏功能密切相关。此外,在纤维化和炎症条件,zyxin可以调节细胞功能和炎症反应。因此,全面了解酶素对于破译信号转导网络和疾病发病机制至关重要。研究其在疾病中的作用有望为早期诊断和治疗策略提供新的途径。然而,靶向zyxin作为治疗焦点在特异性方面提出了挑战,安全,药物输送,和阻力。尽管如此,对zyxin的深入研究和精准医学的应用可以为个性化治疗模式提供新的可能性。
This review highlighted the pivotal role of
zyxin, an essential cell focal adhesions protein, in cellular biology and various diseases.
Zyxin can orchestrate the restructuring and dynamic alterations of the cellular cytoskeleton, which is involved in cell proliferation, adhesion, motility, and gene transcription. Aberrant
zyxin expression is closely correlated with tumor cell activity and cardiac function in both tumorigenesis and cardiovascular diseases. Moreover, in fibrotic and inflammatory conditions,
zyxin can modulate cellular functions and inflammatory responses. Therefore, a comprehensive understanding of zyxin is crucial for deciphering signal transduction networks and disease pathogenesis. Investigating its role in diseases holds promise for novel avenues in early diagnosis and therapeutic strategies. Nevertheless, targeting
zyxin as a therapeutic focal point presents challenges in terms of specificity, safety, drug delivery, and resistance. Nonetheless, in-depth studies on zyxin and the application of precision medicine could offer new possibilities for personalized treatment modalities.