■一种对阿尔茨海默病(AD)危险因素敏感的筛查工具,如淀粉样蛋白-β(Aβ)沉积,和微妙的认知变化,最好由复杂的日常任务引起,是需要的。
■为了确定杂货店购物表现是否可以区分患有AD(OAer)高风险的老年人,患AD(OAlr)风险较低的老年人,和年轻人(YA),Aβ沉积量是否可以预测老年人(OA)的杂货店购物表现。
■21个OAer(78±5年),33OAlr(78±5年),和28YA(31±3年)进行了四次杂货店购物试验,分析了最佳和最差的表现。措施包括审判时间,正确项目的数量,杂货笔记固定的数量,以及固定在正确的搁架单元上的固定次数和固定时间百分比,正确的品牌,和正确的架子。线性混合效应模型按绩效排名比较措施(最佳,最差)和组(OAer,OAlr,YA),并估计了Aβ沉积对OA测量的影响。
■相对于它们的最佳性能,OAer和OAlr在最差的表现中表现出更正确的搁架单元固定和正确的品牌固定,而YA没有。在OA的最差性能范围内,Aβ沉积越大,固定在正确的货架单元上的时间百分比越小,正确的架子,和正确的品牌。在OA内,Aβ沉积增加与杂货笔记固定相关。
■在执行认知要求苛刻的日常任务时,Aβ沉积升高的OA可能表现出微妙的工作记忆障碍和效率较低的视觉搜索策略。
UNASSIGNED: A screening tool sensitive to Alzheimer\'s disease (AD) risk factors, such as amyloid-β (Aβ) deposition, and subtle cognitive changes, best elicited by complex everyday tasks, is needed.
UNASSIGNED: To determine if grocery shopping performance could differentiate older adults at elevated risk of developing AD (OAer), older adults at low risk of developing AD (OAlr), and young adults (YA), and if amount of Aβ deposition could predict grocery shopping performance in older adults (OA).
UNASSIGNED: Twenty-one OAer (78±5 years), 33 OAlr (78±5 years), and 28 YA (31±3 years) performed four grocery shopping trials, with the best and worst performances analyzed. Measures included trial time, number of correct items, number of grocery note fixations, and number of fixations and percentage of time fixating on the correct shelving unit, correct brand, and correct shelf. Linear mixed effects models compared measures by performance rank (best, worst) and group (OAer, OAlr, YA), and estimated the effect of Aβ deposition on measures in OA.
UNASSIGNED: Relative to their best performance, OAer and OAlr exhibited more correct shelving unit fixations and correct brand fixations during their worst performance, while YA did not. Within OA\'s worst performance, greater Aβ deposition was associated with a smaller percentage of time fixating on the correct shelving unit, correct shelf, and correct brand. Within OA, greater Aβ deposition was associated with more grocery note fixations.
UNASSIGNED: OA with elevated Aβ deposition may exhibit subtle working memory impairments and less efficient visual search strategies while performing a cognitively demanding everyday task.