Abstract：
OBJECTIVE: Electroencephalography (EEG) measures of visual evoked potentials (VEPs) provide a targeted approach for investigating neural circuit dynamics. This study separately analyses phase-locked (evoked) and non-phase-locked (induced) gamma responses within the VEP to comprehensively investigate circuit differences in autism.
METHODS: We analyzed VEP data from 237 autistic and 114 typically developing (TD) children aged 6-11, collected through the Autism Biomarkers Consortium for Clinical Trials (ABC-CT). Evoked and induced gamma (30-90 Hz) responses were separately quantified using a wavelet-based time-frequency analysis, and group differences were evaluated using a permutation-based clustering procedure.
RESULTS: Autistic children exhibited reduced evoked gamma power but increased induced gamma power compared to TD peers. Group differences in induced responses showed the most prominent effect size and remained statistically significant after excluding outliers.
CONCLUSIONS: Our study corroborates recent research indicating diminished evoked gamma responses in children with autism. Additionally, we observed a pronounced increase in induced power. Building upon existing ABC-CT findings, these results highlight the potential to detect variations in gamma-related neural activity, despite the absence of significant group differences in time-domain VEP components.
CONCLUSIONS: The contrasting patterns of decreased evoked and increased induced gamma activity in autistic children suggest that a combination of different EEG metrics may provide a clearer characterization of autism-related circuitry than individual markers alone.
METHODS: We analyzed VEP data from 237 autistic and 114 typically developing (TD) children aged 6-11, collected through the Autism Biomarkers Consortium for Clinical Trials (ABC-CT). Evoked and induced gamma (30-90 Hz) responses were separately quantified using a wavelet-based time-frequency analysis, and group differences were evaluated using a permutation-based clustering procedure.
RESULTS: Autistic children exhibited reduced evoked gamma power but increased induced gamma power compared to TD peers. Group differences in induced responses showed the most prominent effect size and remained statistically significant after excluding outliers.
CONCLUSIONS: Our study corroborates recent research indicating diminished evoked gamma responses in children with autism. Additionally, we observed a pronounced increase in induced power. Building upon existing ABC-CT findings, these results highlight the potential to detect variations in gamma-related neural activity, despite the absence of significant group differences in time-domain VEP components.
CONCLUSIONS: The contrasting patterns of decreased evoked and increased induced gamma activity in autistic children suggest that a combination of different EEG metrics may provide a clearer characterization of autism-related circuitry than individual markers alone.
摘要：
目的：视觉诱发电位（VEP）的脑电图（EEG）测量为研究神经回路动力学提供了有针对性的方法。这项研究分别分析了VEP中的锁相（诱发）和非锁相（诱发）伽马响应，以全面研究自闭症的电路差异。
方法：我们分析了237名自闭症患者和114名6-11岁的典型发育（TD）儿童的VEP数据，这些数据是通过自闭症生物标志物临床试验联盟（ABC-CT）收集的。使用基于小波的时频分析分别量化诱发和诱发的伽马（30-90Hz）响应，和组差异使用基于排列的聚类程序进行评估。
结果：与TD同龄人相比，自闭症儿童表现出降低的诱发伽马功率，但增加的诱发伽马功率。诱导反应的组差异显示出最突出的效应大小，并且在排除异常值后仍然具有统计学意义。
结论：我们的研究证实了最近的研究表明自闭症儿童的诱发伽马反应减少。此外,我们观察到诱导功率明显增加。在现有ABC-CT发现的基础上，这些结果突出了检测伽马相关神经活动变化的潜力，尽管时域VEP组分没有显著的组间差异。
结论：自闭症儿童诱发伽玛活动减少和诱发伽玛活动增加的对比模式表明，不同脑电图指标的组合可能比单独的标志物更清楚地表征自闭症相关电路。
方法：我们分析了237名自闭症患者和114名6-11岁的典型发育（TD）儿童的VEP数据，这些数据是通过自闭症生物标志物临床试验联盟（ABC-CT）收集的。使用基于小波的时频分析分别量化诱发和诱发的伽马（30-90Hz）响应，和组差异使用基于排列的聚类程序进行评估。
结果：与TD同龄人相比，自闭症儿童表现出降低的诱发伽马功率，但增加的诱发伽马功率。诱导反应的组差异显示出最突出的效应大小，并且在排除异常值后仍然具有统计学意义。
结论：我们的研究证实了最近的研究表明自闭症儿童的诱发伽马反应减少。此外,我们观察到诱导功率明显增加。在现有ABC-CT发现的基础上，这些结果突出了检测伽马相关神经活动变化的潜力，尽管时域VEP组分没有显著的组间差异。
结论：自闭症儿童诱发伽玛活动减少和诱发伽玛活动增加的对比模式表明，不同脑电图指标的组合可能比单独的标志物更清楚地表征自闭症相关电路。
