目的:通过彩色多普勒成像(CDI)评估原发性开角型青光眼(POAG)患者眼眶血管的变化。
方法:这项横断面研究包括120名受试者-60名POAG患者和60名对照,所有这些人都接受了全面的眼科检查和眼眶CDI。眼动脉(OA),确定了视网膜中央动脉(CRA)和睫状动脉(CA),对于他们每个人来说,我们测量了峰值收缩压速度(PSV),舒张末期速度(EDV)和电阻率指数(RI)。
结果:与正常对照组相比,POAG患者的OA和CRA的PSV显着降低(分别为P<0.0001,<0.009)。OA中的EDV,CRA和CA显著低于正常对照组(P<0.0001)。OA的RI,POAG患者的CRA和CA明显高于对照组(P<0.0001)。OA的EDV与青光眼病程呈负相关(r=-0.37,P<0.042)。CA的EDV与眼压(IOP)呈显着负相关(r=-0.86,P值0.0001)。CRA的PSV和EDV与眼压呈显著负相关(r=-0.45,r=-0.73,P值分别为0.011和0.0001),CRA的RI与眼压呈显著正相关(r=0.42,P值0.021)。
结论:CDI是可行的,非侵入性,评估POAG患者眼眶动脉血流动力学变化的安全工具。与对照组相比,POAG患者的眼眶动脉显示出明显较低的流速和增加的电阻率指数,这些变化与青光眼持续时间和眼压相关。
OBJECTIVE: To assess changes in orbital vessels by Color Doppler Imaging (CDI) in patients with Primary Open Angle Glaucoma (POAG).
METHODS: This cross-sectional study included 120 subjects - 60 patients with POAG and 60 controls, all of whom underwent full ophthalmological examinations and orbital CDI. The Ophthalmic Artery (OA), Central Retinal Artery (CRA) and Ciliary Arteries (CA) were identified, and for each of them, we measured Peak Systolic Velocity (PSV), End Diastolic velocity (EDV) and Resistivity Index (RI).
RESULTS: The PSV of the OA and CRA were significantly lower in patients with POAG compared to normal controls (P<0.0001, < 0.009 respectively). The EDV in the OA, CRA and CA were significantly lower than in normal controls (P<0.0001). The RI of the OA, CRA and CA were significantly higher in patients with POAG compared to controls (P<0.0001). The EDV of the OA showed significant negative correlation with duration of glaucoma (r=-0.37, P<0.042). The EDV of the CA showed significant negative correlation with intraocular pressure (IOP) (r=-0.86 and P value 0.0001). The PSV and EDV of the CRA showed significant negative correlation with IOP (r=-0.45, r=-0.73, P values 0.011, and 0.0001 respectively), and the RI of the CRA showed significant positive correlation with IOP (r=0.42 and P value 0.021).
CONCLUSIONS: CDI is a feasible, noninvasive, safe tool for the assessment of hemodynamic changes in the orbital arteries of POAG patients. The orbital arteries showed significantly lower flow velocities and increased resistivity indices in patients with POAG compared to the control group, and these changes were correlated with glaucoma duration and IOP.