Abstract：
BACKGROUND: Although the role of the vascular component in the pathophysiology of Parkinson\'s disease is widely accepted and retinal vascular abnormalities are commonly observed in Parkinson\'s disease patients, evidence connecting retinal vascular disorders with the risk of developing Parkinson\'s disease is limited. We aimed to investigate the association between retinal vascular occlusion (RVO) and the risk of developing Parkinson\'s disease in people over 60 years using a nationwide cohort.
METHODS: From the 14-year South Korean National Health Insurance Service-Senior cohort, 11 210 incident RVO patients and 11 210 propensity scores, risk-matched controls were included. The incidence of Parkinson\'s disease was estimated with a Poisson regression. A Cox proportional hazards regression model was used to investigate the associations between RVO and the risk of Parkinson\'s disease.
RESULTS: The incidence of Parkinson\'s disease was 664.4 cases per 100 000 person-years (95% confidence interval [CI], 599.7-736.0) in the RVO cohort. Individuals with RVO had an increased incidence of Parkinson\'s disease (hazard ratio [HR], 1.28; 95% CI: 1.10-1.49). Increased PD risk was predominantly observed in retinal artery occlusion patients (HR, 1.53; 95% CI: 1.11-2.12), male patients (HR, 1.67; 95% CI: 1.29-2.17), and 5 years after diagnosis (HR, 1.46; 95% CI: 1.10-1.93).
CONCLUSIONS: Our findings suggest that a common pathophysiological pathway, such as vasculature changes, may exist between RVO and Parkinson\'s disease. RVO may be one of the risk factors associated with future development of Parkinson\'s disease. The nature of this association warrants further investigation.
METHODS: From the 14-year South Korean National Health Insurance Service-Senior cohort, 11 210 incident RVO patients and 11 210 propensity scores, risk-matched controls were included. The incidence of Parkinson\'s disease was estimated with a Poisson regression. A Cox proportional hazards regression model was used to investigate the associations between RVO and the risk of Parkinson\'s disease.
RESULTS: The incidence of Parkinson\'s disease was 664.4 cases per 100 000 person-years (95% confidence interval [CI], 599.7-736.0) in the RVO cohort. Individuals with RVO had an increased incidence of Parkinson\'s disease (hazard ratio [HR], 1.28; 95% CI: 1.10-1.49). Increased PD risk was predominantly observed in retinal artery occlusion patients (HR, 1.53; 95% CI: 1.11-2.12), male patients (HR, 1.67; 95% CI: 1.29-2.17), and 5 years after diagnosis (HR, 1.46; 95% CI: 1.10-1.93).
CONCLUSIONS: Our findings suggest that a common pathophysiological pathway, such as vasculature changes, may exist between RVO and Parkinson\'s disease. RVO may be one of the risk factors associated with future development of Parkinson\'s disease. The nature of this association warrants further investigation.
摘要：
背景：尽管血管成分在帕金森病的病理生理学中的作用已被广泛接受，并且在帕金森病患者中通常观察到视网膜血管异常，将视网膜血管疾病与患帕金森病风险联系起来的证据是有限的。我们的目的是通过一个全国性的队列研究视网膜血管阻塞与60岁以上人群患帕金森病的风险之间的关系。
方法：来自14年的韩国国民健康保险服务-高级队列，11,210例视网膜血管阻塞患者和11,210例倾向评分，纳入风险匹配的对照.使用泊松回归估计帕金森病的发病率。Cox比例风险回归模型用于研究视网膜血管阻塞与帕金森病风险之间的关系。
结果：帕金森氏病的发病率为每100,000人年664.4例（95％置信区间[CI]，599.7-736.0）在视网膜血管阻塞队列中。视网膜血管阻塞患者帕金森病的发病率增加(危险比[HR]，1.28；95%CI，1.10-1.49）。主要在视网膜动脉阻塞患者中观察到PD风险增加（HR，1.53；95%CI，1.11-2.12），男性患者（HR，1.67；95%CI，1.29-2.17），和诊断后5年(HR，1.46；95%CI，1.10-1.93）。
结论：我们的研究结果表明，一个共同的病理生理途径，比如脉管系统的变化,可能存在于视网膜血管阻塞和帕金森病之间。视网膜血管闭塞可能是帕金森病未来发展的危险因素之一。该协会的性质值得进一步调查。
方法：来自14年的韩国国民健康保险服务-高级队列，11,210例视网膜血管阻塞患者和11,210例倾向评分，纳入风险匹配的对照.使用泊松回归估计帕金森病的发病率。Cox比例风险回归模型用于研究视网膜血管阻塞与帕金森病风险之间的关系。
结果：帕金森氏病的发病率为每100,000人年664.4例（95％置信区间[CI]，599.7-736.0）在视网膜血管阻塞队列中。视网膜血管阻塞患者帕金森病的发病率增加(危险比[HR]，1.28；95%CI，1.10-1.49）。主要在视网膜动脉阻塞患者中观察到PD风险增加（HR，1.53；95%CI，1.11-2.12），男性患者（HR，1.67；95%CI，1.29-2.17），和诊断后5年(HR，1.46；95%CI，1.10-1.93）。
结论：我们的研究结果表明，一个共同的病理生理途径，比如脉管系统的变化,可能存在于视网膜血管阻塞和帕金森病之间。视网膜血管闭塞可能是帕金森病未来发展的危险因素之一。该协会的性质值得进一步调查。
