■肥胖,非裔美国人(AA)青少年维生素D缺乏的风险增加。这项初步研究的主要目的是研究补充维生素D对肥胖者25-羟基维生素D(25OHD)水平的影响。AA青少年。
■随机,双盲,对照试点研究包括26名肥胖(BMI≥95%),维生素D缺乏(25OHD<20ng/mL),青春期AA青少年(12-17岁)。受试者每天接受1000IU或5000IU的胆钙化醇,持续3个月。血清25OHD,维生素D结合蛋白,甲状旁腺激素,在基线和治疗后获得心脏代谢风险标志物.
■在注册的39个科目中,26(67%)在基线时维生素D缺乏(平均25OHD12.0±3.8ng/mL),22人完成研究。性,年龄,季节,青春期阶段,BMI,基线时,1000IU组和5000IU组的胰岛素抵抗(HOMA-IR)和25OHD相似.后处理,1000IU组25OHD增加较少(5.6ng/mL,p=0.03)与5000IU组(15.6ng/mL,p=0.002)。5000IU组的83%和1000IU组的30%达到治疗后25OHD≥20ng/mL(p=0.01);5000IU组的50%,但1000IU组没有受试者,达到25OHD≥30ng/mL(p=0.009)。补充后,我们未检测到矿物质代谢物或心脏代谢风险标志物的组间差异。
■在肥胖者中,超过当前医学研究所饮食参考摄入量的胆固醇剂量需要达到25OHD水平≥20ng/mL,AA青少年。可能需要补充5000IU以实现期望的目标。
UNASSIGNED: Obese, African-American (AA) adolescents are at increased risk for vitamin D deficiency. The primary objective of this pilot study was to examine the effect of vitamin D supplementation upon 25-hydroxy vitamin D (25OHD) levels in obese, AA adolescents.
UNASSIGNED: A randomized, double-blinded, controlled pilot study included 26 obese (BMI ≥ 95%ile), vitamin D deficient (25OHD < 20 ng/mL), pubertal AA adolescents (ages 12-17). Subjects received cholecalciferol 1000 IU or 5000 IU daily for 3 months. Serum 25OHD, vitamin D binding protein, parathyroid hormone, and cardiometabolic risk markers were obtained at baseline and post-treatment.
UNASSIGNED: Of 39 subjects enrolled, 26 (67%) were vitamin D deficient (mean 25OHD 12.0 ± 3.8 ng/mL) at baseline and were randomized, with 22 completing the study. Sex, age, season, pubertal stage, BMI, insulin resistance (HOMA-IR) and 25OHD were similar at baseline between the 1000 IU and 5000 IU groups. Post-treatment, 25OHD increased less in the 1000 IU group (5.6 ng/mL, p = 0.03) vs. the 5000 IU group (15.6 ng/mL, p = 0.002). 83% of the 5000 IU group and 30% of the 1000 IU group reached post-treatment 25OHD ≥ 20 ng/mL (p = 0.01); 50% of the 5000 IU group, but no subject from the 1000 IU group, achieved 25OHD ≥ 30 ng/mL (p = 0.009). We detected no group differences in mineral metabolites or cardiometabolic risk markers following supplementation.
UNASSIGNED: Cholecalciferol dosing in excess of the current Institute of Medicine dietary reference intakes was required to achieve 25OHD levels ≥20 ng/mL in obese, AA adolescents. Supplementation of 5000 IU may be required to achieve the desired goal.