PDF(Pubmed)
Abstract：
Neurodegenerative diseases, featured by progressive loss of structure or function of neurons, are considered incurable at present. Movement disorders like tremor and postural instability, cognitive or behavioral disorders such as memory impairment are the most common symptoms of them and the growing patient population of neurodegenerative diseases poses a serious threat to public health and a burden on economic development. Hence, it is vital to prevent the occurrence of the diseases and delay their progress. Vitamin D can be transformed into a hormone in vivo with both genomic and non-genomic actions, exerting diverse physiological effects. Cumulative evidence indicates that vitamin D can ameliorate neurodegeneration by regulating pertinent molecules and signaling pathways including maintaining Ca2+ homeostasis, reducing oxidative stress, inhibiting inflammation, suppressing the formation and aggregation of the pathogenic protein, etc. This review updates discoveries of molecular mechanisms underlying biological functions of vitamin D in neurodegenerative diseases including Alzheimer\'s disease, Parkinson\'s disease, multiple sclerosis, and vascular dementia. Clinical trials investigating the influence of vitamin D supplementation in patients with neurodegenerative diseases are also summarized. The synthesized information will probably provoke an enhanced understanding of the neuroprotective roles of vitamin D in the nervous system and provide therapeutic options for patients with neurodegenerative diseases in the future.
摘要：
神经退行性疾病，以神经元的结构或功能逐渐丧失为特征，目前被认为是无法治愈的。运动障碍，如震颤和姿势不稳，认知或行为障碍，如记忆障碍是最常见的症状，越来越多的神经退行性疾病患者对公共健康构成严重威胁，对经济发展构成负担。因此，预防疾病的发生和延缓其进展至关重要。维生素D可以在体内转化为具有基因组和非基因组作用的激素，发挥不同的生理作用。累积证据表明，维生素D可以通过调节相关分子和信号通路来改善神经变性，包括维持Ca2+稳态。减少氧化应激，抑制炎症，抑制致病蛋白的形成和聚集，等。本文综述了维生素D在包括阿尔茨海默病在内的神经退行性疾病中的生物学功能的分子机制的最新发现。帕金森病,多发性硬化症,和血管性痴呆.还总结了研究补充维生素D对神经退行性疾病患者的影响的临床试验。合成的信息可能会激发人们对维生素D在神经系统中的神经保护作用的理解，并为将来的神经退行性疾病患者提供治疗选择。
