背景:尿路感染(UTI)是尿路疾病的一种流行形式,影响所有年龄和性别的个体。在沙特阿拉伯王国(KSA),尿路感染是医疗保健系统的重大负担,占所有感染的10%,是急诊科入院的第二大原因。尽管如此,在沙特阿拉伯进行了有限的研究,尤其是在Jazan省,位于西南地区。方法:回顾性分析,横断面研究纳入了2022年1月至2023年3月期间在Jazan一家三级医院寻求治疗的尿培养阳性个体.使用标准化的数据收集表格从微生物实验室测试结果和患者的电子病历中检索相关信息。变量,如性别,尿样采集日期,细菌分离物,抗生素敏感性,和耐药性是使用数据收集表收集的。数据采用SPSS软件进行分析,版本23.0(IBMCorp.,Armonk,NY,美国)。结果:共分离鉴定1082例尿液细菌。女性占细菌感染的比例(62.66%)高于男性(37.34%)。革兰氏阴性菌占所有分离菌株的94%。与UTI相关的最常见病原体是大肠杆菌(47.97%),肺炎克雷伯菌(24.58%),铜绿假单胞菌(11.55%)。抗菌素耐药模式表明存在超广谱β-内酰胺酶(ESBL)(30.13%),耐碳青霉烯酶肠杆菌(CRE)(1.94%),耐甲氧西林金黄色葡萄球菌(MRSA)(0.74%),耐万古霉素肠球菌(VRE)(0.18%)。与2022年的其他月份相比,9月份的UTI发病率更高(13%)。大肠杆菌,肺炎克雷伯菌,铜绿假单胞菌是主要的革兰氏阴性多药耐药菌(MDRO),占34.42%,13.95%,和1.63%的人口。结论:耐药微生物引起的UTI在Jazan中的患病率显着。与其他地区的调查结果一致,大肠杆菌仍然是尿路感染最常见的病原体,显示出值得关注的季节性模式。大约35%的报告病例涉及MDRO,ESBLs占30%。这些结果应该引起医疗官员的关注,强调有必要进一步调查导致在Jazan传播MDRO的因素。
Background: Urinary tract infections (UTIs) are a prevalent form of urinary tract diseases affecting individuals of all ages and genders. In the Kingdom of Saudi Arabia (KSA), UTIs are a significant burden on the healthcare system, comprising 10% of all infections and ranking as the second leading cause of emergency department admissions. Despite this, limited research has been conducted in Saudi Arabia, particularly in Jazan Province, located in the southwestern region. Methods: This retrospective, cross-sectional study encompassed individuals with positive urine cultures who sought care at a tertiary hospital in Jazan between January 2022 and March 2023. A standardized data collection form was utilized to retrieve relevant information from microbiology lab test results and patients\' electronic medical records. Variables such as sex, urine sample collection date, bacterial isolates, antibiotic sensitivity, and resistance were collected using the data collection form. Data were analyzed using SPSS software, version 23.0 (IBM Corp., Armonk, NY, USA). Results: A total of 1082 urinary bacterial samples were isolated and identified. Females accounted for more bacterial infections (62.66%) than males (37.34%). Gram-negative bacteria represented 94% of all isolated strains. The most prevalent pathogens associated with UTIs were Escherichia coli (47.97%), Klebsiella pneumoniae (24.58%), and Pseudomonas aeruginosa (11.55%). Antimicrobial resistance patterns indicated the presence of extended-spectrum beta-lactamase (ESBL) (30.13%), carbapenemase-resistant Enterobacter (CRE) (1.94%), methicillin-resistant Staphylococcus aureus (MRSA) (0.74%), and vancomycin-resistant Enterococci (VRE) (0.18%). UTI incidence demonstrated a higher prevalence in September (13%) compared to other months in 2022. Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa were the predominant Gram-negative multidrug-resistant organisms (MDRO), accounting for 34.42%, 13.95%, and 1.63% of the population. Conclusions: The prevalence of UTIs caused by antibiotic-resistant microbes is notable in Jazan. Consistent with findings from other regions, Escherichia coli remains the most common causative pathogen of UTIs, displaying a seasonal pattern that warrants attention. Approximately 35% of reported cases involve MDRO, with ESBLs accounting for 30%. These results should raise concerns among healthcare officials, highlighting the necessity for further investigations into factors contributing to the circulation of MDRO in Jazan.