结直肠癌(CRC)是最常见的消化道肿瘤之一。据报道,microRNAs(miRs)的异位表达在CRC的发生和发展中起着至关重要的作用。此外,研究还表明,miR‑151a‑5p可作为一种有用的生物标志物,用于早期检测和治疗不同类型的癌症,尤其是CRC.然而,miR‑151a‑5p在CRC中的具体作用和潜在机制仍然难以捉摸。当前研究的结果表明,miR‑151a‑5p在CRC细胞系和源自CRC患者的临床组织中上调。功能上,结果显示miR‑151a‑5p显著促进CRC细胞增殖,移民和入侵。此外,双荧光素酶报告基因检测证实,激肽酶(AGMAT)是miR-151a-5p的直接靶标,并且与miR-151a-5p表达呈正相关。机械上,miR‑151a‑5p可以增强CRC细胞的上皮间质转化。一起来看,本研究的结果揭示了一种新的分子机制,表明miR‑151a‑5p/AGMAT轴可能在CRC的调控中起关键作用,因此可被视为CRC的潜在治疗策略.
Colorectal carcinoma (CRC) is one of the most common types of digestive cancer. It has been reported that the ectopic expression of microRNAs (miRs) plays a critical role in the occurrence and progression of CRC. In addition, it has also been suggested that miR‑151a‑5p may serve as a useful biomarker for the early detection and treatment of different types of cancer and particularly CRC. However, the specific effects and underlying mechanisms of miR‑151a‑5p in CRC remain elusive. The results of the current study demonstrated that miR‑151a‑5p was upregulated in CRC cell lines and clinical tissues derived from patients with CRC. Functionally, the results showed that miR‑151a‑5p significantly promoted CRC cell proliferation, migration and invasion. Additionally, dual luciferase reporter assays verified that agmatinase (AGMAT) was a direct target of miR‑151a‑5p and it was positively associated with miR‑151a‑5p expression. Mechanistically, miR‑151a‑5p could enhance the epithelial‑mesenchymal transition of CRC cells. Taken together, the results of the current study revealed a novel molecular mechanism indicating that the miR‑151a‑5p/AGMAT axis could serve a crucial role in the regulation of CRC and could therefore be considered as a potential therapeutic strategy for CRC.