支气管肺发育不良(BPD)是早产儿中最常见的慢性肺部疾病。研究表明,解脲支原体(UU)感染与其发病机制有关。然而,早产儿UU定植是否会增加发生BPD的风险仍存在争议.
■本研究旨在进行系统综述和荟萃分析,以总结UU与BPD之间的相关性。
■我们搜索了PubMed,Embase,Cochrane图书馆,WebofScience,万方数据库,中国国家知识基础设施数据库,中国科技期刊数据库,和中国生物医学光盘从开始到2024年3月15日。我们纳入了队列和病例对照研究,调查早产儿UU感染与BPD之间的关系。遵守系统审查和荟萃分析(PRISMA)指南的首选报告项目。纽卡斯尔-渥太华量表用于质量评估。结果定义为出生后28天(BPD28)或月经后36周(BPD36)继续需要氧气或呼吸支持。考虑到观察性研究中潜在的发表偏倚,我们使用了随机效应元分析模型,评估异质性(I2),进行了亚组分析,评估出版偏见,并对证据质量进行分级.
■荟萃分析包括36项队列研究,包括5,991名参与者。其中,在BPD28上报告了20例,在BPD36上报告了13例,在两者上报告了3例。结果表明UU定植与BPD28之间存在显着关联(优势比(OR):2.26,95%置信区间(CI):1.78-2.85,P<0.00001,23项研究,证据的确定性非常低)和BPD36(OR:2.13,95%CI:1.47-3.07,P<0.0001,16项研究,证据的确定性非常低)。
■UU定植与早产儿BPD的发育之间存在相关性。未来的研究应该优先考虑精心设计,大规模,高质量随机对照试验(RCT)全面评估UU感染后新生儿BPD的风险,并为临床筛查和预防策略提供更有力的证据,以改善受影响新生儿的预后。
■https://www.crd.约克。AC.英国/,标识符(CRD42024524846)。
UNASSIGNED: Bronchopulmonary dysplasia (BPD) is the most prevalent chronic lung disease in preterm infants. Studies have shown that Ureaplasma urealyticum (UU) infection is linked to its pathogenesis. However, it remains controversial whether UU colonization in preterm infants increases the risk of developing BPD.
UNASSIGNED: This study aimed to conduct a systematic review and meta-analysis to summarize the correlation between UU and BPD.
UNASSIGNED: We searched PubMed, Embase, the Cochrane Library, Web of Science, Wanfang Database, Chinese National Knowledge Infrastructure Database, Chinese Science and Technique Journal Database, and the China Biology Medicine disc from their inception to March 15, 2024. We included cohort and case-control studies investigating the association between UU infections and BPD in preterm infants, adhering to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The Newcastle-Ottawa Scale was used for quality assessment. The outcome was defined as the continued need for oxygen or respiratory support at 28 days after birth (BPD28) or at 36 weeks postmenstrual age (BPD36). Considering the potential publication bias in observational studies, we used a random-effects meta-analysis model, assessed heterogeneity (I2), performed subgroup analyses, evaluated publication bias, and graded the quality of evidence.
UNASSIGNED: The meta-analysis included 36 cohort studies encompassing 5,991 participants. Among these, 20 reported on BPD28, 13 on BPD36, and 3 on both. The results indicated a significant association between UU colonization and BPD28 (odds ratio (OR): 2.26, 95% confidence interval (CI): 1.78-2.85, P < 0.00001, 23 studies, very low certainty of evidence) and BPD36 (OR: 2.13, 95% CI: 1.47-3.07, P < 0.0001, 16 studies, very low certainty of evidence).
UNASSIGNED: There is a correlation between UU colonization and the development of BPD in preterm infants. Future research should prioritize well-designed, large-scale, high-quality randomized controlled trials (RCTs) to comprehensively assess the risk of BPD in neonates following UU infection and to provide stronger evidence for clinical screening and prevention strategies to improve the prognosis of affected newborns.
UNASSIGNED: https://www.crd.york.ac.uk/, identifier (CRD42024524846).