Abstract：
BACKGROUND: Breast cancer stands as a leading contributor to global cancer-related mortality. Progressing Research and Medical Innovations Elevate Treatment Choices and Results for Breast Cancer. Among these, Peimine, a natural steroid inherent in plants, notably within the Fritillaria species, demonstrates the capability to trigger apoptosis in breast cancer cells through the mitochondrial membrane permeation pathway. Nevertheless, its impact on an appropriate cancer model remains an area necessitating further exploration.
OBJECTIVE: This study explored the in vivo anticancer effects of peimine on MRMT-1 Cell-line induced breast cancer in rats.
METHODS: Cancer was induced by the administration of MRMT-1 (6 x 106 cells) cells in the mammary pads of SD rats. The daily drug treatmentcommenced on day 14 and continued till 39 days. Peimine was administered in two doses (0.24 mg/kg and 0.48 mg/kg p.o) to examine its efficacy in curing breast cancer while tamoxifen was used as standard.
RESULTS: A reduction in tumour size was observed in the peimine-treated groups. Peimine can correct the changed blood cell count in addition to its anti-tumour activity. In peimine-treated rats, imbalanced immune marker IgE, serum oxidative marker, and tissue apoptotic markers like cytochrome c and calcium level were shown to be restored significantly.
CONCLUSIONS: Our findings imply that quinine has beneficial effects as an anti-neoplastic medication for breast cancer, most likely through its apoptotic activity. More research is necessary to thoroughly understand their mechanisms of action, ideal dose, and potential side effects.
OBJECTIVE: This study explored the in vivo anticancer effects of peimine on MRMT-1 Cell-line induced breast cancer in rats.
METHODS: Cancer was induced by the administration of MRMT-1 (6 x 106 cells) cells in the mammary pads of SD rats. The daily drug treatmentcommenced on day 14 and continued till 39 days. Peimine was administered in two doses (0.24 mg/kg and 0.48 mg/kg p.o) to examine its efficacy in curing breast cancer while tamoxifen was used as standard.
RESULTS: A reduction in tumour size was observed in the peimine-treated groups. Peimine can correct the changed blood cell count in addition to its anti-tumour activity. In peimine-treated rats, imbalanced immune marker IgE, serum oxidative marker, and tissue apoptotic markers like cytochrome c and calcium level were shown to be restored significantly.
CONCLUSIONS: Our findings imply that quinine has beneficial effects as an anti-neoplastic medication for breast cancer, most likely through its apoptotic activity. More research is necessary to thoroughly understand their mechanisms of action, ideal dose, and potential side effects.
摘要：
背景：乳腺癌是全球癌症相关死亡率的主要贡献者。进步的研究和医学创新提高了乳腺癌的治疗选择和结果。其中,Peimine,植物固有的天然类固醇，特别是在贝母物种中，证明了通过线粒体膜渗透途径触发乳腺癌细胞凋亡的能力。然而，它在适当的癌症模型中的影响仍然是一个需要进一步探索的领域。
目的：本研究探讨培美素对MRMT-1细胞诱导的大鼠乳腺癌的体内抗癌作用。
方法:通过在SD大鼠的乳腺垫中施用MRMT-1(6×106个细胞)细胞来诱导癌症。每日药物治疗在第14天开始，一直持续到39天。以两种剂量（0.24mg/kg和0.48mg/kgp.o）给药，以检查其在治疗乳腺癌中的功效，同时将他莫昔芬用作标准品。
结果：在培明治疗组中观察到肿瘤大小的减小。Peimine除了具有抗肿瘤活性外，还可以纠正改变的血细胞计数。在培明治疗的大鼠中，免疫标志物IgE失衡,血清氧化标志物，细胞色素c和钙水平等组织凋亡标志物显示显着恢复。
结论：我们的发现暗示奎宁作为一种治疗乳腺癌的抗肿瘤药物具有有益的作用，最有可能是通过其凋亡活性。需要更多的研究来彻底了解它们的作用机制,理想剂量,和潜在的副作用。
目的：本研究探讨培美素对MRMT-1细胞诱导的大鼠乳腺癌的体内抗癌作用。
方法:通过在SD大鼠的乳腺垫中施用MRMT-1(6×106个细胞)细胞来诱导癌症。每日药物治疗在第14天开始，一直持续到39天。以两种剂量（0.24mg/kg和0.48mg/kgp.o）给药，以检查其在治疗乳腺癌中的功效，同时将他莫昔芬用作标准品。
结果：在培明治疗组中观察到肿瘤大小的减小。Peimine除了具有抗肿瘤活性外，还可以纠正改变的血细胞计数。在培明治疗的大鼠中，免疫标志物IgE失衡,血清氧化标志物，细胞色素c和钙水平等组织凋亡标志物显示显着恢复。
结论：我们的发现暗示奎宁作为一种治疗乳腺癌的抗肿瘤药物具有有益的作用，最有可能是通过其凋亡活性。需要更多的研究来彻底了解它们的作用机制,理想剂量,和潜在的副作用。
