Treatment and services

  • 文章类型: Journal Article
    背景:已知智力/发育障碍(IDD)患者的处方药使用率很高,特别是精神药物。由于与这些药物相关的许多副作用以及多重用药的风险,这是令人担忧的。在本文中,我们比较了患有IDD的年轻人与没有IDD的年轻人的最常用分配药物和所有精神药物。
    方法:使用10年期间的人口级行政卫生数据,这项研究调查了与未患有IDD的青少年相比,向15~24岁患有IDD的青少年分配的药物.确定了分配的最常见药物和分配给他们的青年人数。还检查了各种各样的精神药物。
    结果:共有20.591名患有IDD的青年和1.293.791名没有IDD的青年。患有IDD的年轻人被分配止痛药的几率更高,阿莫西林,沙丁胺醇,左甲状腺素和所有的精神药物(抗抑郁药,抗精神病药,抗焦虑药,抗肾上腺素药,情绪稳定剂和兴奋剂)。对于患有IDD的年轻人来说,6558人(31.85%)在一年内配发两种或两种以上不同的精神药物,与无IDD青年的75.963(5.87%)相比。
    结论:与没有缺碘症的年轻人相比,患有IDD的年轻人被分配大多数研究的处方药的几率明显更高,包括所有的精神药物。在同一年内,他们从不同类别的精神药物中分配两种或多种药物的可能性也是原来的两倍。这些发现对IDD患者及其医疗保健提供者的健康具有重要意义。
    BACKGROUND: People with intellectual/developmental disabilities (IDD) are known to have high rates of prescription drug use, particularly for psychotropic medications. This is of concern due to the many side effects associated with these medications and because of the risks of polypharmacy. In this paper we compare the most commonly dispensed drugs and all psychotropic medications for youth with IDD compared with youth without IDD.
    METHODS: Using population-level administrative health data over a 10-year period, this study examined medications dispensed to youth with an IDD aged 15-24 years compared with youth without an IDD. The most common medications dispensed and the number of youth they were dispensed to were determined. As well a wide variety of psychotropic medications were examined.
    RESULTS: There were a total of 20 591 youth with IDD and 1 293 791 youth without IDD identified. Youth with IDD had higher odds of being dispensed pain medications, amoxicillin, salbutamol, levothyroxine and all the psychotropic medications (antidepressants, antipsychotics, anxiolytics, anti-adrenergic agents, mood stabilisers and stimulants). For youth with IDD, 6558 (31.85%) were dispensed two or more different psychotropic medications within a year, compared with 75 963 (5.87%) of youth without IDD.
    CONCLUSIONS: Compared to youth without IDD, youth with IDD had significantly higher odds of being dispensed most of the prescription medications studied, including all of the psychotropic medications. They were also twice as likely to be dispensed two or more medications from different classes of psychotropic drugs within the same year. These findings have important implications for the health of people with IDD and for their health care providers.
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  • 文章类型: Journal Article
    背景:运动控制问题对于智障人士(PWID)来说很常见,导致日常生活的基本活动困难,包括吃。咀嚼,这对消化和整体健康至关重要,在这个人群中了解甚少。PWID显示出与老年人相似的脆弱,强调将咀嚼运动控制与老年人进行比较的重要性。这项研究比较了中年人咀嚼肌的神经肌肉控制,PWID和老年人。
    方法:使用横截面分析设计。在胡萝卜片(直径2厘米,重量0.5克)的咀嚼任务中,表面肌电图用于记录左右咬肌和颞肌的肌肉活动模式。主成分分析(PCA)用于评估神经肌肉控制。对PCA的第一成分方差进行z评分归一化,以识别神经肌肉控制改变的个体。进行混合方差分析以评估主成分之间的相互作用,群体和身体组成。
    结果:30名PWID(35-55岁),我们招募了中年人和32名老年人.与中年对照成人相比,PWID和老年人对咀嚼肌的神经肌肉控制降低(P<0.05)。与老年人(19%)和中年人(0%)相比,PWID的咀嚼肌神经肌肉控制改变的个体比例最高(53%)(P<0.05)。
    结论:我们的结果表明,与中年人相比,PWID和老年人的神经肌肉控制能力降低。值得注意的是,与老年人相比,大部分PWID显示咀嚼肌控制改变.需要进一步的研究来探索咀嚼肌训练对PWID的潜在益处。
    Motor control issues are common for people with intellectual disabilities (PWID), resulting in difficulties with basic activities of daily living, including eating. Mastication, which is crucial for digestion and overall health, is poorly understood in this population. PWID shows frailty similar to older people, highlighting the importance of comparing masticatory motor control with older adults. This study compared the neuromuscular control of the masticatory muscles in middle-aged, PWID and older adults.
    A cross-sectional analytical design was used. During the mastication task of a carrot piece (2 cm in diameter and weighing 0.5 g), surface electromyography was used to record muscle activity patterns from the right and left masseter and temporalis muscles. Principal component analysis (PCA) was used to assess neuromuscular control. A z-score normalisation of the first component\'s variance from PCA to identify those individuals with altered neuromuscular control. A mixed ANOVA was performed to assess the interaction between principal components, groups and body composition.
    Thirty PWIDs (aged 35-55 years), middle-aged adults and 32 older adults were recruited. PWID and older adults showed decreased neuromuscular control of the masticatory muscles compared to middle-aged control adults (P < 0.05). PWID had the highest proportion of individuals with altered neuromuscular control of the masticatory muscle (53%) compared to older adults (19%) and middle-aged adults (0%) (P < 0.05).
    Our results indicate that PWID and older adults have reduced neuromuscular control compared to middle-aged adults. Notably, a significant proportion of the PWID showed altered masticatory muscle control compared to older adults. Further research is needed to explore the potential benefits of masticatory muscle training for PWID.
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  • 文章类型: Journal Article
    背景:远程医疗(即跨距离使用技术)在许多领域都很普遍。尽管它正在为智力或发育障碍(IDD)的人提供行为支持,没有已知的研究来研究利益相关者对此的看法。
    方法:与11名专业人员和6名IDD儿童家庭照顾者进行了四轮Delphi咨询,以就影响参与者使用远程健康进行行为支持达成共识。数据是在冠状病毒大流行之前收集的。
    结果:36个项目对专业人员达成共识(26个优点和10个缺点/障碍),22个项目对家庭照顾者达成共识(8个优点和14个缺点/障碍)。还针对缺点/障碍确定了一系列解决方案。
    结论:参与者愿意使用远程健康作为行为支持。然而,缺点/障碍需要解决,需要有关远程医疗在这一领域的使用的指南。我们报告了一些实践建议,包括在可能的情况下将远程医疗与现场支持相结合,结合视频技术,并考虑客户的观点和对远程医疗方法的信心。
    Telehealth (i.e. the use of technology across distance) is widespread in many fields. Although its use for behavioural support for people with intellectual or developmental disabilities (IDD) is emerging, there are no known studies examining stakeholder perceptions of this.
    A four-round Delphi consultation was conducted with 11 professionals and six family carers of children with IDD to generate consensus on what would influence participants\' use of telehealth for behavioural support. Data were collected prior to the coronavirus pandemic.
    Thirty-six items reached consensus for professionals (26 advantages and 10 disadvantages/barriers) and 22 for family carers (8 advantages and 14 disadvantages/barriers). A range of solutions were also identified for the disadvantages/barriers.
    Participants were willing to use telehealth for behavioural support. However, disadvantages/barriers need to be addressed, and guidelines relating to the use of telehealth in this field are needed. We report a number of practice recommendations including combining telehealth with in-person supports where possible, incorporating video technologies, and considering client perspectives and confidence with telehealth methodologies.
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  • 文章类型: Journal Article
    背景:随着Rett综合征的临床试验正在进行中,有必要验证反映重要体征和症状的潜在补充结局指标.自主神经功能障碍,尤其是血管舒缩功能障碍,是可以开发生物标志物的一个潜在领域。
    方法:在目前的研究中,26名患有Rett综合征(年龄62个月至39岁)的女性的手和脚的红外热图像,和17位没有知识分子的女性,收集遗传或神经系统疾病(年龄55个月至39岁).组间皮肤温度的差异,Rett综合征组皮肤温度测量的时间稳定性,评估了皮肤温度测量值与父母报告和研究人员评估的自主神经功能障碍指标之间的关系。
    结果:组间差异显示Rett综合征组的手脚温度较低。随着时间的推移,手部温度测量值稳定,并且与父母报告的自主神经症状中度相关。脚温测量比手的温度变化更大,但与父母报告的自主神经症状具有更强的相关性。
    结论:该结果为Rett综合征中手足皮肤温度测量的可靠性和有效性提供了初步支持。需要额外的研究来复制这些结果,并评估这些措施在较短时间尺度上的时间稳定性。
    As clinical trials for Rett syndrome are underway, there is a need to validate potential supplemental outcome measures that reflect important signs and symptoms. Autonomic dysfunction, particularly vasomotor dysfunction, is one potential area for which biomarkers could be developed.
    In the current study, infrared thermal images of hands and feet from 26 females with Rett syndrome (aged 62 months to 39 years), and 17 females without known intellectual, genetic or neurological disorders (aged 55 months to 39 years) were collected. Between-group differences in skin temperature, and temporal stability of skin temperature measures in the Rett syndrome group, and relationships between skin temperature measures and parent-reported and researcher-evaluated indicators of autonomic dysfunction were evaluated.
    Between-group differences showed lower hand and foot temperatures in the Rett syndrome group. Hand temperature measurements were stable over time and were moderately correlated with parent-reported autonomic symptoms. Foot temperature measurements were more variable than hand temperatures but showed stronger correlations with parent-reported autonomic symptoms.
    The results provide preliminary support for the reliability and validity of hand and foot skin temperature measures in Rett syndrome. Additional research is needed to replicate these results and evaluate the temporal stability of these measures over shorter time scales.
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