■随着全球老龄化人口的增加,阿尔茨海默病已经成为一个迅速增加的公共卫生问题。在2019年全球疾病负担研究中,有三个风险因素被认为与阿尔茨海默病和其他痴呆症有因果关系:吸烟,高体重指数(HBMI),和高空腹血糖(HFPG)。
■本研究旨在分析1990年至2019年中国各地AD死亡率和相关负担的趋势,以及它们与年龄的相关性。period,和出生队列。
■数据是从GBD2019中提取的。使用Joinpoint回归分析归因于代谢风险(HFPG和HBMI)和吸烟的AD死亡率趋势。使用年龄周期队列(APC)模型评估队列和周期效应。
■从1990年到2019年,AD的总体年龄标准化死亡率上升,尤其是女性。由于净漂移中的吸烟,AD死亡率增加,女性(0.46,95CI=[0.09,0.82])比男性(-0.03,95CI=[-0.11,0.05])更显著。对于HFPG的原因,男性和女性的净漂移值分别为0.82%和0.43%。对于HBMI,分别为3.14%和2.76%,分别,反映了AD死亡率的大幅增加。
■从1990年到2019年,中国由代谢风险和吸烟引起的AD死亡率的时间趋势一直在增加。因此,在生命的后期有必要防止体重过度增加和肥胖,尤其是女性。
UNASSIGNED: With the increase in the aging population worldwide, Alzheimer\'s disease has become a rapidly increasing public health concern. In the Global Burden of Disease Study 2019, there are three risk factors judged to have evidence for a causal link to Alzheimer\'s disease and other dementias: smoking, high body-mass index (HBMI), and high fasting plasma glucose (HFPG).
UNASSIGNED: This study aimed to analyze trends in AD mortality and the relevant burden across China from 1990 to 2019, as well as their correlation with age, period, and birth cohort.
UNASSIGNED: The data were extracted from the GBD 2019. Trends in AD mortality attributable to metabolic risks (HFPG and HBMI) and smoking were analyzed using Joinpoint regression. The age-period-cohort (APC) model was used to evaluate cohort and period effects.
UNASSIGNED: From 1990 to 2019, the overall age-standardized mortality rate of AD increased, especially in women. There was an increase in AD mortality due to smoking in the net drift, and it was more significant in women (0.46, 95%CI = [0.09, 0.82]) than men (-0.03, 95%CI = [-0.11, 0.05]). For the cause of HFPG, the net drift values for men and women were 0.82% and 0.43%. For HBMI, the values were 3.14% and 2.76%, respectively, reflecting substantial increases in AD mortality.
UNASSIGNED: Time trends in AD mortality caused by metabolic risks and smoking in China from 1990 to 2019 have consistently increased. Therefore, it is necessary to prevent excessive weight gain and obesity during the later stages of life, especially for females.